IMPC phenotypes (gene matching)
C.129P2-Ccr2tm1Blck/Biat
| Status | Available to order |
| EMMA ID | EM:11133 |
| Citation information | RRID:IMSR_EM:11133 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.129P2-Ccr2tm1Blck/Biat |
| Alternative name | 2-Cd |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ccr2tm1Blck |
| Gene/Transgene symbol | Ccr2 |
Information from provider
| Provider | Bruno Luckow |
| Provider affiliation | Nephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV |
| Genetic information | The chemokine receptor Ccr2 has been inactivated by homologous recombination in ES cells. The mutant mice have been backcrossed to the BALB/c genetic background. The floxed neo selection cassette has been deleted by cre-mediated recombination in backcross generation N10+F3. Contains a functioning autofluorescent EGFP reporter gene. |
| Phenotypic information | Homozygous:Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Upregulated in many infectious and inflammatory diseases. Important role in leukocyte chemotaxis and innate immunity.Heterozygous:Unknown, but most likely wildtype phenotype |
| Breeding history | Currently maintained on the background of BALB/cAnNCrl, N16+F15 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous BALB/c;129P2/OlaHsd males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- altered response to myocardial infarction / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- weight loss / MGI
- retinal degeneration / MGI
- abnormal osteoclast physiology / MGI
- hepatic necrosis / MGI
- multifocal hepatic necrosis / MGI
- liver inflammation / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- increased IgG level / MGI
- alcohol aversion / MGI
- abnormal monocyte morphology / MGI
- abnormal immune serum protein physiology / MGI
- abnormal conditioned taste aversion behavior / MGI
- increased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased tumor growth/size / MGI
- increased alcohol consumption / MGI
- decreased alcohol consumption / MGI
- abnormal leukocyte adhesion / MGI
- abnormal microglial cell physiology / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- increased hepatocyte apoptosis / MGI
- liver hemorrhage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- abnormal osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- abnormal wound healing / MGI
- diarrhea / MGI
- decreased acute inflammation / MGI
- decreased T cell proliferation / MGI
- abnormal optic choroid morphology / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal cholesterol homeostasis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- decreased circulating creatinine level / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- retinal deposits / MGI
- abnormal choriocapillaris morphology / MGI
- abnormal urine protein level / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased dendritic cell number / MGI
- abnormal osteoclast differentiation / MGI
- retinal photoreceptor degeneration / MGI
- retinal outer nuclear layer degeneration / MGI
- increased susceptibility to induced colitis / MGI
- decreased susceptibility to induced colitis / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased common myeloid progenitor cell number / MGI
- lipofuscinosis / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased splenocyte proliferation / MGI
- increased trabecular bone thickness / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal bone mineral density / MGI
- abnormal dendritic cell chemotaxis / MGI
- abnormal macrophage chemotaxis / MGI
- abnormal bone trabecula morphology / MGI
- increased trabecular bone volume / MGI
- increased fluid intake / MGI
- increased CD11b-high dendritic cell number / MGI
- decreased CD11b-high dendritic cell number / MGI
- impaired leukocyte tethering or rolling / MGI
Literature references
- Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice.;Pérez de Lema Guillermo, Maier Holger, Franz Tobias J, Escribese Maríia, Chilla Silvia, Segerer Stephan, Camarasa Natalia, Schmid Holger, Banas Bernhard, Kalaydjiev Svetoslav, Busch Dirk H, Pfeffer Klaus, Mampaso Francisco, Schlöndorff Detlef, Luckow Bruno, ;2005;Journal of the American Society of Nephrology : JASN;16;3592-601; 16267157