Available to order

International strain nameB6.FVB-Tg(Camk2a-cre)2Gsc/Cnrm
Alternative nameCamk2a-iCre BAC (CKC)
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Camk2a-cre)2Gsc,
Gene/Transgene symbolTg(Camk2a-cre)2Gsc

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationBAC transgene expressing the icre recombinase under the control of the Camk2a promoter (BAC line).
Phenotypic informationnot obvious
  • A CamKIIalpha iCre BAC allows brain-specific gene inactivation.;Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart A F, Schütz G, ;2001;Genesis (New York, N.Y. : 2000);31;37-42; 11668676

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

  • A CamKIIalpha iCre BAC allows brain-specific gene inactivation.;Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart A F, Schütz G, ;2001;Genesis (New York, N.Y. : 2000);31;37-42; 11668676
  • A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.;Fusco Salvatore, Ripoli Cristian, Podda Maria Vittoria, Ranieri Sofia Chiatamone, Leone Lucia, Toietta Gabriele, McBurney Michael W, Schütz Günther, Riccio Antonella, Grassi Claudio, Galeotti Tommaso, Pani Giovambattista, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;621-6; 22190495
  • Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.;Godinho-Silva Cristina, Domingues Rita G, Rendas Miguel, Raposo Bruno, Ribeiro Hélder, da Silva Joaquim Alves, Vieira Ana, Costa Rui M, Barbosa-Morais Nuno L, Carvalho Tânia, Veiga-Fernandes Henrique, ;2019;Nature;574;254-258; 31534216
  • The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.;Zhang Jianmin, Wang Yue, Chi Zhikai, Keuss Matthew J, Pai Ying-Min Emily, Kang Ho Chul, Shin Joo-Ho, Bugayenko Artem, Wang Hong, Xiong Yulan, Pletnikov Mikhail V, Mattson Mark P, Dawson Ted M, Dawson Valina L, ;2011;Cell;145;284-99; 21496646
  • Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line.;Matsuura Ken, Mohamed Haytham M A, Youssef Mohieldin M M, Yoshida Yutaka, Yamamoto Tadashi, ;2022;iScience;25;104692; 35856033
  • Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.;Cedernaes Jonathan, Huang Wenyu, Ramsey Kathryn Moynihan, Waldeck Nathan, Cheng Lei, Marcheva Biliana, Omura Chiaki, Kobayashi Yumiko, Peek Clara Bien, Levine Daniel C, Dhir Ravindra, Awatramani Raj, Bradfield Christopher A, Wang Xiaozhong A, Takahashi Joseph S, Mokadem Mohamad, Ahima Rexford S, Bass Joseph, ;2019;Cell metabolism;29;1078-1091.e5; 30827863
  • Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.;Takaoka Shohei, Yanagiya Akiko, Mohamed Haytham Mohamed Aly, Higa Rei, Abe Takaya, Inoue Ken-Ichi, Takahashi Akinori, Stoney Patrick, Yamamoto Tadashi, ;2021;iScience;24;103151; 34646989

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
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  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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