B6J.B6N(Cg)-Rps6ka5tm1.1Arte/H
| Status | Available to order |
| EMMA ID | EM:13015 |
| International strain name | B6J.B6N(Cg)-Rps6ka5tm1.1Arte/H |
| Alternative name | MSK1 Kinase Dead (MSK1 KD) |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Rps6ka5tm1.1Arte |
| Gene/Transgene symbol | Rps6ka5 |
Information from provider
| Provider | Simon Arthur |
| Provider affiliation | School of Life Sciences, University of Dundee |
| Genetic information | A kinase-dead MSK1 mouse was generated by mutating Asp194 to Ala in the endogenous MSK1 (Rps6ka5) gene. The knock-in was produced by TaconicArtemis using standard targeting methods in C57BL/6 ES cells. |
| Phenotypic information | Homozygous:Mice have impaired hippocampal synaptic transmission and greater dendritic spine density (CA1), but no obvious behavioural or LTP/LTD phenotype.Heterozygous:Not tested. |
| Breeding history | Mice originally derived from C57BL/6N have been backcrossed with C57BL/6J for at least 6 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.;Hunter Chris J, Remenyi Judit, Correa Sonia A, Privitera Lucia, Reyskens Kathleen M S E, Martin Kirsty J, Toth Rachel, Frenguelli Bruno G, Arthur J Simon C, ;2017;FEBS open bio;7;821-834; 28593137
- MSK1 regulates homeostatic and experience-dependent synaptic plasticity.;Corrêa Sonia A L, Hunter Christopher J, Palygin Oleg, Wauters Sandrine C, Martin Kirsty J, McKenzie Colin, McKelvey Kim, Morris Richard G M, Pankratov Yuriy, Arthur J Simon C, Frenguelli Bruno G, ;2012;The Journal of neuroscience : the official journal of the Society for Neuroscience;32;13039-51; 22993422
- The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.;Daumas Stephanie, Hunter Christopher J, Mistry Rajen B, Morè Lorenzo, Privitera Lucia, Cooper Daniel D, Reyskens Kathleen M, Flynn Harry T, Morris Richard G M, Arthur J Simon C, Frenguelli Bruno G, ;2017;eNeuro;4;4644-4660; 28275711
- Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.;Privitera Lucia, Morè Lorenzo, Cooper Daniel D, Richardson Philippa, Tsogka Marianthi, Hebenstreit Daniel, Arthur J Simon C, Frenguelli Bruno G, ;2020;The Journal of neuroscience : the official journal of the Society for Neuroscience;40;6031-6072; 32376781
- MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.;Morè Lorenzo, Privitera Lucia, Cooper Daniel D, Tsogka Marianthi, Arthur J Simon C, Frenguelli Bruno G, ;2023;Aging;15;110110; 37432063
- MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF.;Morè Lorenzo, Privitera Lucia, Lopes Marcia, Arthur J Simon C, Lauterborn Julie C, Corrêa Sonia A L, Frenguelli Bruno G, ;2024;Neuropharmacology;261;; 39128584