C57BL/6NTac-Atp1a3em1H/H
Status | Available to order |
EMMA ID | EM:13025 |
International strain name | C57BL/6NTac-Atp1a3em1H/H |
Alternative name | Atp1a3-E818K-EM1-B6N |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Atp1a3em1H |
Gene/Transgene symbol | Atp1a3 |
Information from provider
Provider | MRC-Harwell |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:UnknownHeterozygous:None |
Breeding history | Co-isogenic on original background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome / Orphanet_1171
- Rapid-onset dystonia-parkinsonism / Orphanet_71517
- Alternating hemiplegia of childhood / Orphanet_2131
- Non-specific early-onset epileptic encephalopathy / Orphanet_442835
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- tremors / MGI
- paralysis / MGI
- abnormal temporal lobe morphology / MGI
- abnormal dentate gyrus morphology / MGI
- convulsive seizures / MGI
- decreased body weight / MGI
- decreased body size / MGI
- decreased anxiety-related response / MGI
- ataxia / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- short stride length / MGI
- decreased exploration in new environment / MGI
- abnormal spatial learning / MGI
- abnormal startle reflex / MGI
- abnormal sleep pattern / MGI
- limb grasping / MGI
- increased thermal nociceptive threshold / MGI
- seizures / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal respiratory function / MGI
- abnormal sensorimotor gating / MGI
- increased thigmotaxis / MGI
- abnormal long term object recognition memory / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- astrocytosis / MGI
- abnormal response to novel object / MGI
- nervous system phenotype / MGI
- enhanced coordination / MGI
- impaired passive avoidance behavior / MGI
- abnormal neuron physiology / MGI
- abnormal behavior / MGI
- dystonia / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal action potential / MGI
- abnormal enzyme/coenzyme activity / MGI
- abnormal spike wave discharge / MGI
- abnormal xenobiotic pharmacokinetics / MGI
- microgliosis / MGI
- decreased prepulse inhibition / MGI
- abnormal seizure response to inducing agent / MGI
- environmentally induced seizures / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- impaired contextual conditioning behavior / MGI
- enhanced conditioned place preference behavior / MGI
- enhanced behavioral response to addictive substance / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal hippocampus granule cell morphology / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- neonatal lethality, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal habituation / MGI
- abnormal habituation to a new environment / MGI
- abnormal sensitization to xenobiotic / MGI
- decreased frequency of paradoxical sleep / MGI
- abnormal paradoxical sleep pattern / MGI
- abnormal non-rapid eye movement sleep pattern / MGI
- impaired spatial learning / MGI
- increased kindling response / MGI
- prolonged circadian behavior period / MGI
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