C57BL/6J-Appem7H/H

Status

Available to order

EMMA IDEM:14611
International strain nameC57BL/6J-Appem7H/H
Alternative nameAPP-MABH-EM7-B6
Strain typeEndonuclease-mediated
Allele/Transgene symbolAppem7H
Gene/Transgene symbolApp

Information from provider

Provider MRC-Harwell
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • increased cornea thickness / IMPC
  • decreased total retina thickness / IMPC
  • short tibia / IMPC
  • increased circulating calcium level / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased grip strength / IMPC
MGI phenotypes (gene matching)
  • amyloidosis / MGI
  • muscle degeneration / MGI
  • decreased corpus callosum size / MGI
  • abnormal telencephalon morphology / MGI
  • decreased body weight / MGI
  • increased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • impaired swimming / MGI
  • intracerebral hemorrhage / MGI
  • abnormal learning/memory/conditioning / MGI
  • abnormal fear/anxiety-related behavior / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • gliosis / MGI
  • absent corpus callosum / MGI
  • abnormal brain commissure morphology / MGI
  • abnormal long term potentiation / MGI
  • abnormal emotion/affect behavior / MGI
  • increased thigmotaxis / MGI
  • abnormal active avoidance behavior / MGI
  • abnormal long term object recognition memory / MGI
  • abnormal neuron morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal locomotor activation / MGI
  • amyloid beta deposits / MGI
  • astrocytosis / MGI
  • nervous system phenotype / MGI
  • impaired passive avoidance behavior / MGI
  • myositis / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal cell physiology / MGI
  • decreased hippocampal commissure size / MGI
  • decreased anterior commissure size / MGI
  • abnormal spatial reference memory / MGI
  • hematoma / MGI
  • microgliosis / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal synapse morphology / MGI
  • decreased grip strength / MGI
  • altered susceptibility to induced thrombosis / MGI
  • abnormal circadian behavior / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).