- increased KLRG1-positive NK cell number / IMPC
- decreased mature B cell number / IMPC
- abnormal optic disk morphology / IMPC
- increased monocyte cell number / IMPC
- increased KLRG1+ CD4 alpha-beta T cell number / IMPC
- decreased transitional stage B cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased circulating creatinine level / IMPC
- increased pulmonary respiratory rate / IMPC
- increased KLRG1+ CD8 alpha-beta T cell number / IMPC
- hyperactivity / IMPC
- increased effector memory T-helper cell number / IMPC
- decreased regulatory T cell number / IMPC
- increased eosinophil cell number / IMPC
- decreased memory-marker CD4-negative NK T cell number / IMPC
- decreased food intake / IMPC
- increased CD4-positive, alpha-beta memory T cell number / IMPC
- increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- decreased B cell number / IMPC
- increased neutrophil cell number / IMPC
- increased memory-marker CD4-negative NK T cell number / IMPC
- decreased CD4-negative NK T cell number / IMPC
- increased NK cell number / IMPC
- increased memory-marker NK cell number / IMPC
- increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- immune system phenotype / IMPC
- decreased Ly6C-positive immature NK cell number / IMPC
- increased circulating alkaline phosphatase level / IMPC
- decreased circulating glucose level / IMPC
- decreased B-1a cell number / IMPC
- decreased follicular B cell number / IMPC
- increased CD8-positive, alpha-beta memory T cell number / IMPC
- decreased exploration in new environment / IMPC
- short tibia / IMPC
- increased circulating amylase level / IMPC
- increased CD11b-low dendritic cell number / IMPC
- increased KLRG1-positive CD4-negative NK T cell number / IMPC
- increased grip strength / IMPC
- decreased CD11b-high dendritic cell number / IMPC
- increased KLRG1-positive gamma-delta T cell number / IMPC
- increased NK T cell number / IMPC
- decreased bone mineral density / IMPC
- decreased vertical activity / IMPC
- limb grasping / IMPC
- decreased prepulse inhibition / IMPC
- increased CD103-positive CD11b-low dendritic cell number / IMPC
- increased granulocyte number / IMPC
- increased Ly6C low monocyte number / IMPC
- decreased CD8-positive, naive alpha-beta T cell number / IMPC
- increased circulating iron level / IMPC
- increased Ly6C high monocyte number / IMPC
- decreased marginal zone B cell number / IMPC
- increased macrophage cell number / IMPC
- decreased respiratory quotient / IMPC
- decreased memory-marker NK cell number / IMPC
- increased circulating aspartate transaminase level / IMPC
- thrombocytosis / IMPC
- decreased Ly6C-positive mature NK cell number / IMPC
- increased immature B cell number / IMPC
- decreased NK T cell number / IMPC
- increased circulating unsaturated transferrin level / IMPC
- decreased B-2 B cell number / IMPC
- decreased bone mineral content / IMPC
- abnormal bone structure / IMPC
C57BL/6J-Bach2em1H/H
Status | Available to order |
EMMA ID | EM:14612 |
International strain name | C57BL/6J-Bach2em1H/H |
Alternative name | BACH2-G26K-EM1-B6 |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Bach2em1H |
Gene/Transgene symbol | Bach2 |
Information from provider
Provider | MRC-Harwell |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:not knownHeterozygous:None reported |
Breeding history | Co-isogenic on original background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- spleen hypoplasia / MGI
- decreased IgG level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- abnormal B cell physiology / MGI
- increased IgM level / MGI
- abnormal somatic hypermutation frequency / MGI
- abnormal class switch recombination / MGI
- decreased B cell number / MGI
- absent germinal center B cells / MGI
- decreased marginal zone B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- myeloid hyperplasia / MGI
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