C57BL/6NTac-Pla2g6em1H/H

Status

Available to order

EMMA IDEM:14639
International strain nameC57BL/6NTac-Pla2g6em1H/H
Alternative namePLA2G6-R636Q-EM1-B6N
Strain typeEndonuclease-mediated
Allele/Transgene symbolPla2g6em1H
Gene/Transgene symbolPla2g6

Information from provider

Provider MRC-Harwell
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
  • kyphosis / MGI
  • tremors / MGI
  • hindlimb paralysis / MGI
  • abnormal spinal cord morphology / MGI
  • weight loss / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • increased exploration in new environment / MGI
  • abnormal motor coordination/balance / MGI
  • impaired limb coordination / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • blindness / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • neurodegeneration / MGI
  • muscular atrophy / MGI
  • abnormal sciatic nerve morphology / MGI
  • asthenozoospermia / MGI
  • axonal dystrophy / MGI
  • abnormal locomotor coordination / MGI
  • abnormal nervous system morphology / MGI
  • abnormal myelin sheath morphology / MGI
  • increased cholesterol level / MGI
  • decreased double-positive T cell number / MGI
  • abnormal spinal cord ventral horn morphology / MGI
  • abnormal brainstem morphology / MGI
  • abnormal axon morphology / MGI
  • axon degeneration / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal brain white matter morphology / MGI
  • abnormal spinal cord grey matter morphology / MGI
  • abnormal synaptic bouton morphology / MGI
  • abnormal astrocyte physiology / MGI
  • skeletal muscle atrophy / MGI
  • axonal spheroids / MGI
  • decreased grip strength / MGI
  • abnormal apolipoprotein level / MGI
  • abnormal mitochondrial crista morphology / MGI
  • abnormal cell cytoskeleton morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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