- male infertility / IMPC
C57BL/6NTac-Pla2g6em1H/H
Status | Available to order |
EMMA ID | EM:14639 |
International strain name | C57BL/6NTac-Pla2g6em1H/H |
Alternative name | PLA2G6-R636Q-EM1-B6N |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Pla2g6em1H |
Gene/Transgene symbol | Pla2g6 |
Information from provider
Provider | MRC-Harwell |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:not knownHeterozygous:None reported |
Breeding history | Co-isogenic on original background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Infantile neuroaxonal dystrophy / Orphanet_35069
- Adult-onset dystonia-parkinsonism / Orphanet_199351
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- kyphosis / MGI
- tremors / MGI
- hindlimb paralysis / MGI
- abnormal spinal cord morphology / MGI
- weight loss / MGI
- ataxia / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased exploration in new environment / MGI
- abnormal motor coordination/balance / MGI
- impaired limb coordination / MGI
- reduced male fertility / MGI
- male infertility / MGI
- blindness / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- abnormal sciatic nerve morphology / MGI
- asthenozoospermia / MGI
- axonal dystrophy / MGI
- abnormal locomotor coordination / MGI
- abnormal nervous system morphology / MGI
- abnormal myelin sheath morphology / MGI
- increased cholesterol level / MGI
- decreased double-positive T cell number / MGI
- abnormal spinal cord ventral horn morphology / MGI
- abnormal brainstem morphology / MGI
- abnormal axon morphology / MGI
- axon degeneration / MGI
- abnormal mitochondrion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal spinal cord grey matter morphology / MGI
- abnormal synaptic bouton morphology / MGI
- abnormal astrocyte physiology / MGI
- skeletal muscle atrophy / MGI
- axonal spheroids / MGI
- decreased grip strength / MGI
- abnormal apolipoprotein level / MGI
- abnormal mitochondrial crista morphology / MGI
- abnormal cell cytoskeleton morphology / MGI
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