C57BL/6NTac-Sqstm1em1H/H

Status

Available to order

EMMA IDEM:14650
International strain nameC57BL/6NTac-Sqstm1em1H/H
Alternative nameSQSTM1-G331D-EM1-B6N
Strain typeEndonuclease-mediated
Allele/Transgene symbolSqstm1em1H
Gene/Transgene symbolSqstm1

Information from provider

Provider MRC-Harwell
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased body length / IMPC
  • abnormal behavior / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased circulating glucose level / IMPC
  • process of degenerative change / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • hypoplasia / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased lean body mass / IMPC
  • decreased circulating LDL cholesterol level / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased hemoglobin content / IMPC
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • kyphosis / MGI
  • lordosis / MGI
  • increased body length / MGI
  • increased body weight / MGI
  • abnormal osteoclast physiology / MGI
  • hyperglycemia / MGI
  • premature death / MGI
  • abnormal bone mineralization / MGI
  • increased susceptibility to age related obesity / MGI
  • oxidative stress / MGI
  • premature aging / MGI
  • abnormal bone structure / MGI
  • abnormal compact bone morphology / MGI
  • abnormal behavior / MGI
  • abnormal osteoclast morphology / MGI
  • increased osteoclast cell number / MGI
  • decreased osteoclast cell number / MGI
  • decreased oxygen consumption / MGI
  • impaired glucose tolerance / MGI
  • skeleton phenotype / MGI
  • decreased circulating glucose level / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • increased circulating leptin level / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal bone ossification / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased interleukin-6 secretion / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • increased neuron number / MGI
  • rough coat / MGI
  • abnormal respiratory electron transport chain / MGI
  • abnormal aerobic respiration / MGI
  • increased food intake / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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