- increased body length / IMPC
- abnormal behavior / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- decreased circulating glucose level / IMPC
- process of degenerative change / IMPC
- increased circulating alkaline phosphatase level / IMPC
- hypoplasia / IMPC
- decreased circulating HDL cholesterol level / IMPC
- decreased circulating cholesterol level / IMPC
- increased lean body mass / IMPC
- decreased circulating LDL cholesterol level / IMPC
- decreased mean corpuscular volume / IMPC
- decreased hemoglobin content / IMPC
C57BL/6NTac-Sqstm1em1H/H
Status | Available to order |
EMMA ID | EM:14650 |
International strain name | C57BL/6NTac-Sqstm1em1H/H |
Alternative name | SQSTM1-G331D-EM1-B6N |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Sqstm1em1H |
Gene/Transgene symbol | Sqstm1 |
Information from provider
Provider | MRC-Harwell |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:not knownHeterozygous:None reported |
Breeding history | Co-isogenic on original background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Amyotrophic lateral sclerosis / Orphanet_803
- Frontotemporal dementia with motor neuron disease / Orphanet_275872
- Behavioral variant of frontotemporal dementia / Orphanet_275864
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- kyphosis / MGI
- lordosis / MGI
- increased body length / MGI
- increased body weight / MGI
- abnormal osteoclast physiology / MGI
- hyperglycemia / MGI
- premature death / MGI
- abnormal bone mineralization / MGI
- increased susceptibility to age related obesity / MGI
- oxidative stress / MGI
- premature aging / MGI
- abnormal bone structure / MGI
- abnormal compact bone morphology / MGI
- abnormal behavior / MGI
- abnormal osteoclast morphology / MGI
- increased osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- decreased oxygen consumption / MGI
- impaired glucose tolerance / MGI
- skeleton phenotype / MGI
- decreased circulating glucose level / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased circulating leptin level / MGI
- abnormal mitochondrial physiology / MGI
- abnormal bone ossification / MGI
- abnormal osteoclast differentiation / MGI
- decreased interleukin-6 secretion / MGI
- decreased subcutaneous adipose tissue amount / MGI
- increased neuron number / MGI
- rough coat / MGI
- abnormal respiratory electron transport chain / MGI
- abnormal aerobic respiration / MGI
- increased food intake / MGI
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