B6.Cg-Tg(Cdh5-cre/ERT2)1Rha/H
| Status | Available to order |
| EMMA ID | EM:14891 |
| International strain name | B6.Cg-Tg(Cdh5-cre/ERT2)1Rha/H |
| Alternative name | C57BL/6-Tg(Cdh5-Cre/ERT2)1Rha |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cdh5-cre/ERT2)1Rha, |
| Gene/Transgene symbol | Tg(Cdh5-cre/ERT2)1Rha |
Information from provider
| Provider | Ralf Adams |
| Provider affiliation | Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine |
| Genetic information | An inducible cre deleter under the control of the vascular endothelial cadherin (Cdh5(PAC)) promoter; cre recombination is induced upon administration of tamoxifen. Useful for the study of angiogenesis, atherosclerosis and neovascularisation. Non-induced Cdh5(PAC)-creERT2 mice show absence of cre recombinase activity, while tamoxifen-induced Cdh5(PAC)-creERT2 mice show high levels of recombinase-mediated gene deletion in vascular endothelial cells (95%+). |
| Phenotypic information | Homozygous:Not knownHeterozygous:Normal appearance |
| Breeding history | Founder lines were backcrossed to C57BL/6 for at least 10 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.;Wang Yingdi, Nakayama Masanori, Pitulescu Mara E, Schmidt Tim S, Bochenek Magdalena L, Sakakibara Akira, Adams Susanne, Davy Alice, Deutsch Urban, Lüthi Urs, Barberis Alcide, Benjamin Laura E, Mäkinen Taija, Nobes Catherine D, Adams Ralf H, ;2010;Nature;465;483-6; 20445537
- Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice.;Pitulescu Mara E, Schmidt Inga, Benedito Rui, Adams Ralf H, ;2010;Nature protocols;5;1518-34; 20725067