B6.Cg-Tg(Cdh5-cre/ERT2)1Rha/H

Status

Available to order

EMMA IDEM:14891
International strain nameB6.Cg-Tg(Cdh5-cre/ERT2)1Rha/H
Alternative nameC57BL/6-Tg(Cdh5-Cre/ERT2)1Rha
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Cdh5-cre/ERT2)1Rha
Gene/Transgene symbolTg(Cdh5-cre/ERT2)1Rha

Information from provider

ProviderRalf Adams
Provider affiliationTissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Genetic informationAn inducible cre deleter under the control of the vascular endothelial cadherin (Cdh5(PAC)) promoter; cre recombination is induced upon administration of tamoxifen. Useful for the study of angiogenesis, atherosclerosis and neovascularisation. Non-induced Cdh5(PAC)-creERT2 mice show absence of cre recombinase activity, while tamoxifen-induced Cdh5(PAC)-creERT2 mice show high levels of recombinase-mediated gene deletion in vascular endothelial cells (95%+).
Phenotypic informationHomozygous:
Not known

Heterozygous:
Normal appearance
Breeding historyFounder lines were backcrossed to C57BL/6 for at least 10 generations.
References
  • Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.;Wang Yingdi, Nakayama Masanori, Pitulescu Mara E, Schmidt Tim S, Bochenek Magdalena L, Sakakibara Akira, Adams Susanne, Davy Alice, Deutsch Urban, Lüthi Urs, Barberis Alcide, Benjamin Laura E, Mäkinen Taija, Nobes Catherine D, Adams Ralf H, ;2010;Nature;465;483-6; 20445537
  • Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice.;Pitulescu Mara E, Schmidt Inga, Benedito Rui, Adams Ralf H, ;2010;Nature protocols;5;1518-34; 20725067
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.;Wang Yingdi, Nakayama Masanori, Pitulescu Mara E, Schmidt Tim S, Bochenek Magdalena L, Sakakibara Akira, Adams Susanne, Davy Alice, Deutsch Urban, Lüthi Urs, Barberis Alcide, Benjamin Laura E, Mäkinen Taija, Nobes Catherine D, Adams Ralf H, ;2010;Nature;465;483-6; 20445537
  • Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice.;Pitulescu Mara E, Schmidt Inga, Benedito Rui, Adams Ralf H, ;2010;Nature protocols;5;1518-34; 20725067

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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