B6;CBA-Tg(Cyp1a1-cre)1Dwi/H

Status

Available to order

EMMA IDEM:14903
International strain nameB6;CBA-Tg(Cyp1a1-cre)1Dwi/H
Alternative nameTg(Cyp1a1-cre)1Dwi -Published as (AhCre)
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Cyp1a1-cre)1Dwi
Gene/Transgene symbolTg(Cyp1a1-cre)1Dwi

Information from provider

ProviderDouglas Winton
Provider affiliationCancer Research UK Cambridge Institute, University of Cambridge
Genetic informationAn AhCre transgene vector, containing the cre recombinase coding sequence under the rat CYP1A1 promoter, was injected into fertilized C57BL/6 x CBA oocytes. Founder mice were backcrossed onto C57BL/6 mice to establish transgenic lines. Heterozygous transgenic lines were interbred to establish homozygous AhCre mice.
Phenotypic informationHomozygous:
None breeds to homozygosity

Heterozygous:
No phenotype
Breeding historyThe line was cryopreserved many years ago. It was created around 2002/3 by pronuclear injection of B6 x CBA embryos and maintained as pairs of trios mainly comprised of transgenic males crossed to wild-type females. Initial wild-type breeders were B6. But the line is not congenic to B6.
References
  • Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783
  • Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783
  • Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

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