C57BL/6J-Acanem1H/H

Status

Available to order

EMMA IDEM:15113
International strain nameC57BL/6J-Acanem1H/H
Alternative nameACAN-NVTEGA-EM1-B6J
Strain typeEndonuclease-mediated
Allele/Transgene symbolAcanem1H
Gene/Transgene symbolAcan

Information from provider

Provider MRC-Harwell
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal organ of Corti morphology / MGI
  • cleft palate / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal vertebrae morphology / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal rib morphology / MGI
  • kyphosis / MGI
  • lordosis / MGI
  • abnormal cartilage development / MGI
  • abnormal chondrocyte morphology / MGI
  • short snout / MGI
  • flattened snout / MGI
  • short limbs / MGI
  • abnormal liver morphology / MGI
  • enlarged liver / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal lung morphology / MGI
  • pulmonary hypoplasia / MGI
  • obese / MGI
  • distended abdomen / MGI
  • abnormal gait / MGI
  • aphagia / MGI
  • cardiac hypertrophy / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • deafness / MGI
  • premature death / MGI
  • abnormal limb morphology / MGI
  • abnormal craniofacial bone morphology / MGI
  • no abnormal phenotype detected / MGI
  • disproportionate dwarf / MGI
  • brachydactyly / MGI
  • brachypodia / MGI
  • abnormal joint morphology / MGI
  • short femur / MGI
  • abnormal tracheal cartilage morphology / MGI
  • decreased susceptibility to induced arthritis / MGI
  • polyhydramnios / MGI
  • abnormal intervertebral disk morphology / MGI
  • short humerus / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • absent cochlear outer hair cells / MGI
  • absent caudal vertebrae / MGI
  • intervertebral disk degeneration / MGI
  • decreased length of long bones / MGI
  • short vertebral column / MGI
  • small thoracic cavity / MGI
  • abnormal cochlear IHC afferent innervation pattern / MGI
  • cardiomyopathy / MGI
  • abnormal limb development / MGI
  • protruding tongue / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • short basicranium / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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