- decreased body weight / MGI
- postnatal growth retardation / MGI
- reduced female fertility / MGI
- abnormal ovulation / MGI
- decreased litter size / MGI
- no phenotypic analysis / MGI
- immune system phenotype / MGI
- increased cardiac muscle contractility / MGI
- impaired neutrophil recruitment / MGI
- impaired neutrophil chemotaxis / MGI
- abnormal tumor necrosis factor level / MGI
- postnatal lethality, incomplete penetrance / MGI
C57BL/6J-Pde4dem1H/H
Status | Available to order |
EMMA ID | EM:15126 |
International strain name | C57BL/6J-Pde4dem1H/H |
Alternative name | Pde4d-S185A-EM1-B6J |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Pde4dem1H |
Gene/Transgene symbol | Pde4d |
Information from provider
Provider | MRC-Harwell |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Breeding history | Co-isogenic on original background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- PDE4D haploinsufficiency syndrome / Orphanet_439822
- Acrodysostosis with multiple hormone resistance / Orphanet_280651
- Acrodysostosis / Orphanet_950
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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