STOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl

Status

Available to order

EMMA IDEM:15297
International strain nameSTOCK Slc34a2tm-Nhch Tg(Vil1-cre)20Syr/Orl
Alternative nameB6N.Cg-Tg(Vil1-cre)20Syr/J (#033019) x B6;129-Slc34a2 tm1Nhch; Short name: NaPillb-villin
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSlc34a2tm-Nhch, Tg(Vil1-cre)20Syr
Gene/Transgene symbolSlc34a2, Tg(Vil1-cre)20Syr

Information from provider

ProviderNati Hernando
Provider affiliationPhysiology, University Zurich
Genetic informationMice expressing cre recombinase under constitutive control of the mouse villin promoter, as well as two loxP sites inserted into intron 9 and exon 13 (the last one downstream the stop codon) of Slc34a2, the gene encoding the sodium/phosphate cotransporter NaPi-IIb.
Phenotypic informationHomozygous:
Increased fecal excretion of phosphate and reduced urinary excretion of phosphate.

Heterozygous:
No phenotype.
Breeding historyHomozygous mice breed normally, 1 backcross to C57BL/6J.
References
  • Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.;Hernando Nati, Myakala Komuraiah, Simona Fabia, Knöpfel Thomas, Thomas Linto, Murer Heini, Wagner Carsten A, Biber Jürg, ;2015;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;30;1925-37; 25827490
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6.129

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Literature references

  • Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.;Hernando Nati, Myakala Komuraiah, Simona Fabia, Knöpfel Thomas, Thomas Linto, Murer Heini, Wagner Carsten A, Biber Jürg, ;2015;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;30;1925-37; 25827490

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).