- abnormal blood vessel morphology / IMPC
- microphthalmia / IMPC
- increased lymphocyte cell number / IMPC
- abnormal placenta morphology / IMPC
- abnormal kidney morphology / IMPC
- abnormal limb morphology / IMPC
- increased leukocyte cell number / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal skin morphology / IMPC
- embryonic growth retardation / IMPC
- enlarged spleen / IMPC
- increased monocyte cell number / IMPC
- abnormal placenta size / IMPC
- abnormal eyelid morphology / IMPC
- cataract / IMPC
- enlarged testis / IMPC
- enlarged kidney / IMPC
- abnormal testis morphology / IMPC
- abnormal vitreous body morphology / IMPC
- abnormal spleen morphology / IMPC
- persistence of hyaloid vascular system / IMPC
- decreased circulating creatinine level / IMPC
- edema / IMPC
C57BL/6NTac-Cxcr4em2H/H
Status | Available to order |
EMMA ID | EM:15585 |
International strain name | C57BL/6NTac-Cxcr4em2H/H |
Alternative name | C57BL/6NTac-Cxcr4em2H/H |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Cxcr4em2H |
Gene/Transgene symbol | Cxcr4 |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | As reported by Mouse Genome Informatics, Cxcr4, a protein coding gene, codes for C-X-C chemokine receptor 4 and is associated with WHIM syndrome, cardiomyopathy and congestive heart failure in both mice and humans. ERT2 cassette knock-in to the existing Cxcr4-CRE-EM1-B6N allele, made by CRISPR/Cas9 gene editing via pronuclear injection of reagents into 1-cell stage embryo. |
Phenotypic information | Homozygous:To be confirmedHeterozygous:To be confirmed |
Breeding history | Incepient congenic on maintained background |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- WHIM syndrome / Orphanet_51636
IMPC phenotypes (gene matching)
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