IMPC phenotypes (gene matching)
- decreased locomotor activity / IMPC
C57BL/6N-Tubg1tm1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:15627 |
| Citation information | RRID:IMSR_EM:15627 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Tubg1tm1Ics/Ics |
| Alternative name | Tubg1tm1(Y92C)Ics (G4583) |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Tubg1tm1Ics |
| Gene/Transgene symbol | Tubg1 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This line was obtained by modification of TB1 in house derived C57BL/6N embryonic stem cells. Exon 2 (ENSMUSE00000970617) and 3 (ENSMUSE00000989844) were floxed and a point mutation (TAC to TGC) corresponding to the Y92C mutation was introduced in exon 3. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:lethalHeterozygous:DOI: 10.3390/biomedicines10123148 and DOI: 10.1038/s41467-019-10081-8 |
| Breeding history | Inbred C57BL/6N |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Literature references
- TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.;Ivanova Ekaterina L, Gilet Johan G, Sulimenko Vadym, Duchon Arnaud, Rudolf Gabrielle, Runge Karen, Collins Stephan C, Asselin Laure, Broix Loic, Drouot Nathalie, Tilly Peggy, Nusbaum Patrick, Vincent Alexandre, Magnant William, Skory Valerie, Birling Marie-Christine, Pavlovic Guillaume, Godin Juliette D, Yalcin Binnaz, Hérault Yann, Dráber Pavel, Chelly Jamel, Hinckelmann Maria-Victoria, ;2019;Nature communications;10;2129; 31086189