C57BL/6J-Itpr1em2H/H
Status | Available to order |
EMMA ID | EM:15628 |
International strain name | C57BL/6J-Itpr1em2H/H |
Alternative name | C57BL/6J-Itpr1em2H/H |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Itpr1em2H |
Gene/Transgene symbol | Itpr1 |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | Itpr1, a protein coding gene, codes for inositol 1,4,5-triphosphate receptor type 1 and its human ortholog ITPR1 is associated with Gillespie syndrome, spinocerebellar ataxia type 15 and spinocerebellar ataxia type 29 in humans. This is a CRISPR/Cas9 induced mutation creating a series of point mutations; G2545R in exon ENSMUSE00000407938 of ITPR1. The stock was generated at MRC Harwell via microinjection of CRISPR/Cas9 reagents into 1-cell stage embryos. |
Phenotypic information | Homozygous:To be determinedHeterozygous:To be determined |
Breeding history | crossed once to C57BL/6J after electroporation. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
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