C57BL/6J-Pcdh19em2H/H

Status

Available to order

EMMA IDEM:15699
International strain nameC57BL/6J-Pcdh19em2H/H
Alternative name C57BL/6J-Pcdh19/H
Strain typeEndonuclease-mediated
Allele/Transgene symbolPcdh19em2H
Gene/Transgene symbolPcdh19

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationAs reported by Mouse Genome Informatics, Pcdh19, a protein coding gene, codes for protocadherin-19 and is associated with developmental and epileptic encephalopathy in Humans. This line was generated by introducing a Knock-in of ddCre into the 5' UTR of Pcdh19 made by CRISPR/Cas9 gene editing. The knock-in was introduced via pronuclear injection into 1-cell stage embryo.
Phenotypic informationHomozygous:
To be determined

Heterozygous:
To be determined
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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