B6.129P2(SJL)-Del(10Prmt2-Col6a1)1Yah/Orl

Status	Available to order
EMMA ID	EM:01808
Citation information	RRID:IMSR_EM:01808 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129P2(SJL)-Del(10Prmt2-Col6a1)1Yah/Orl
Alternative name	Del(Hrmt1l1-Col6a1)Ms1Yah
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Del(10Prmt2-Col6a1)1Yah
Gene/Transgene symbol	Del(10Prmt2-Col6a1)1Yah

Information from provider

Provider	Yann HERAULT
Provider affiliation	TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models
Genetic information	Deletion of the region between the Hrmt1l1 (Prmt2) and Col6a1 genes engineered using Mutagenic Insertion and Chromosome Engineering Resource (MICER) in ES (HM1) cells.
Phenotypic information	Homozygotes: early embryonic lethal. Heterozygotes: no major defects.
Breeding history	Deletion generated in 129P2 HM1 ES cells. Cells injected in C57BL/6 blastocysts. Backcrossed to C57BL/6 (N7).
References	Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625 Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310 A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.;Raza Mir A, Folz Andrew, Victorino Daniella B, Xing Zhuo, Chen Xu-Qiao, Zuo Xinxin, Borden Leah K, Potier Marie-Claude, Mobley William, Dierssen Mara, Hiratsuka Masaharu, Kazuki Yasuhiro, Welshhans Kristy, Maugham-Macan Michelle, Tramutola Antonella, Okun Eitan, Reeves Roger, Roper Randall J, Yu Y Eugene, Hérault Yann, Tybulewicz Victor L J, Fisher Elizabeth M C, Sathyanesan Aaron, ;2026;STAR protocols;7;104717; 42501327

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)

decreased hematocrit / MGI
lung inflammation / MGI
abnormal respiratory system physiology / MGI
respiratory system inflammation / MGI
abnormal macrophage physiology / MGI
growth/size/body region phenotype / MGI
behavior/neurological phenotype / MGI
abnormal cytokine level / MGI
increased red blood cell distribution width / MGI

MGI phenotypes (gene matching)

decreased hematocrit / MGI
lung inflammation / MGI
abnormal respiratory system physiology / MGI
respiratory system inflammation / MGI
abnormal macrophage physiology / MGI
growth/size/body region phenotype / MGI
behavior/neurological phenotype / MGI
abnormal cytokine level / MGI
increased red blood cell distribution width / MGI

Literature references

Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.;Besson Vanessa, Brault Véronique, Duchon Arnaud, Togbe Dieudonné, Bizot Jean-Charles, Quesniaux Valérie F J, Ryffel Bernard, Hérault Yann, ;2007;Human molecular genetics;16;2040-52; 17591625
Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310
A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.;Raza Mir A, Folz Andrew, Victorino Daniella B, Xing Zhuo, Chen Xu-Qiao, Zuo Xinxin, Borden Leah K, Potier Marie-Claude, Mobley William, Dierssen Mara, Hiratsuka Masaharu, Kazuki Yasuhiro, Welshhans Kristy, Maugham-Macan Michelle, Tramutola Antonella, Okun Eitan, Reeves Roger, Roper Randall J, Yu Y Eugene, Hérault Yann, Tybulewicz Victor L J, Fisher Elizabeth M C, Sathyanesan Aaron, ;2026;STAR protocols;7;104717; 42501327

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Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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