STOCK Hnf4atm1(cre)Sdv/H
Status | Available to order |
EMMA ID | EM:02506 |
International strain name | STOCK Hnf4atm1(cre)Sdv/H |
Alternative name | Hnf4 cre |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Hnf4atm1(cre)Sdv, |
Gene/Transgene symbol | Hnf4a |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
Genetic information | Strain carries a knock-in of cre recombinase into the Hnf4a locus. Strain expresses Cre efficiently in the hepatocytes of the developing liver to allow conditional gene deletion or activation in this lineage. |
Phenotypic information | Homozygous lethal at mid gestation due to defects in liver formation. |
Breeding history | Backcrossed on a 129S/SvEv background. |
References | None available |
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- HNF1B-related autosomal dominant tubulointerstitial kidney disease / Orphanet_93111
- MODY / Orphanet_552
- Hyperinsulinism due to HNF4A deficiency / Orphanet_263455
- Atypical Fanconi syndrome-neonatal hyperinsulinism syndrome / Orphanet_544628
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