B6;129S7-Prnptm1Cwe/CweOrl

Status

Available to order

EMMA IDEM:05303
International strain nameB6;129S7-Prnptm1Cwe/CweOrl
Alternative namePrp-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPrnptm1Cwe,
Gene/Transgene symbolPrnp

Information from provider

ProviderAdriano Aguzzi
Provider affiliationUniv.Hosp.Zurich/Inst.Neuropathology
Genetic informationGeneration of Prnp (PrP) knock-out mice. Disruption of Prnp allele of ES cells by homologous recombination. 4.8 kb genomic sequence was replaced by neo gene under the HSV TK promoter. Homozygous breeding.
References
  • Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.;Büeler H, Fischer M, Lang Y, Bluethmann H, Lipp H P, DeArmond S J, Prusiner S B, Aguet M, Weissmann C, ;1992;Nature;356;577-82; 1373228

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous 129 x C57BL/6, heterozygous 129 x C57BL/6
Breeding at archiving centreA sub-strain with the same mutation and genetic background is maintained at the repository CNR, Consiglio Nazionale delle Ricerche, Monterotondo Scalo, Roma, Italy: EM:00158

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term potentiation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased brain copper level / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • decreased Purkinje cell number / MGI

Literature references

  • Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.;Büeler H, Fischer M, Lang Y, Bluethmann H, Lipp H P, DeArmond S J, Prusiner S B, Aguet M, Weissmann C, ;1992;Nature;356;577-82; 1373228

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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