IMPC phenotypes (gene matching)
B6.129P2-Plod1Gt(RST531)Byg/Oulu
| Status | Available to order |
| EMMA ID | EM:08328 |
| Citation information | RRID:IMSR_EM:08328 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Plod1Gt(RST531)Byg/Oulu |
| Alternative name | Plod1Gt(RST531)Byg |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Plod1Gt(RST531)Byg |
| Gene/Transgene symbol | Plod1 |
Information from provider
| Provider | Raija Soininen |
| Provider affiliation | Biocenter Oulu, University of Oulu |
| Genetic information | Gene-trap insertion into intron 11 of the Plod1 gene. |
| Phenotypic information | Homozygous:Homozygotes were not analyzed.Heterozygous:Heterozygotes were used for expression analyses (X-gal staining), other analyses were not performed. |
| Breeding history | Backcrossed, N=10 |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous 129P2/OlaHsd x C57BL/6 males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency / Orphanet_1900
MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
MGI phenotypes (gene matching)
- paralysis / MGI
- hemorrhage / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- no phenotypic analysis / MGI
- aortic dissection / MGI
- hypotonia / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- abnormal aorta smooth muscle morphology / MGI
- abnormal aorta wall morphology / MGI
Literature references
- Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice.;Takaluoma Kati, Hyry Marjo, Lantto Juha, Sormunen Raija, Bank Ruud A, Kivirikko Kari I, Myllyharju Johanna, Soininen Raija, ;2007;The Journal of biological chemistry;282;6588-96; 17197443