Better understanding of laboratory animal genetics will improve reproducibility

A new perspective article published in PLoS Biology by INFRAFRONTIER nodes Mary Lyon Centre at MRC Harwell and PHENOMIN-ICS highlights gaps in the genetic characterisation of laboratory animals that can compromise reproducibility.

The authors also highlight that the same issue with model characterisation and reporting also exist in in vitro models. The study discusses three solutions to enhance research quality and reproducibility when using genetically altered models: improved training in genetics, increased investment in model characterisation, and comprehensive documentation following the LAG-R guidelines for genetic reporting.

Original publication:
Pavlovic G, Wells S, Hérault Y, Teboul L (2025) Better understanding of laboratory animal genetics will improve reproducibility. PLoS Biol 23(10): e3003464. https://doi.org/10.1371/journal.pbio.3003464.