Central role of Creld1 in mammalian heart development and function

Thursday, 6 May 2021



Scientists from the University of Bonn in collaboration with colleagues from Radboud University, Nijmegen and the German Mouse Clinic showed, that Creld1, the first single gene linked to atrioventricular septal defects (AVSD) of newborn, regulates myocardial development and function in mice.

Due to the embryonic lethality of global Creld1 knockout (KO) in mice, the researchers generated either conditional Creld1 KO mice lacking Creld1 in the endocardium (KOTie2) or the myocardium (KOMyHC). The mutant mice underwent a cardiac phenotyping combined with biochemical, cellular and molecular examinations to find out the function of Creld1 in the myocardium and endocardium. It turned out, that Creld1 in the myocardium is essential for cardiac function and survival, the mutant mice died early postnatally due to myocardial hypoplasia. In contrast to that, Creld1 function in the endocardium was shown to be dispensable for heart development.

The entire article can be found here: https://www.mouseclinic.de/news/news-from-the-gmc/article/28505/index.html 

Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Händler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D. Creld1 regulates myocardial development and function. J Mol Cell Cardiol. 2021 Mar 24;156:45-56