As part of the International Mouse Phenotyping Consortium (IMPC), researchers from Helmholtz Zentrum München led by Prof. Hrabě de Angelis, have uncovered a large number of novel genes controlling the mineral density of bone. Because bone mineral density is low in patients with osteoporosis, these findings will help to better understand the underlying molecular mechanisms of the disease. The new insight is important to advance precision medicine for people affected by osteoporosis in terms of prevention and therapeutic options.
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Swan et al., “Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral “; PLoS Genet. 2020 Dec 28;16(12):e1009190. doi: 10.1371/journal.pgen.1009190. Epub ahead of print. PMID: 33370286.