
COVID-19 Resources and Measures
To combat the rapidly evolving COVID-19 pandemic, INFRAFRONTIER is offering, free-of-charge open calls, several resources, COVID-19-related strains and emergency archiving services to the global research community with the aim to aid COVID-19 research and minimise the loss of valuable mouse strains during the crisis.
Trans-national Access Call: COVID-19 Therapeutics Pipeline
With more than 1.5 million deaths by the end of 2020 and no signs of slowing down, the COVID-19 pandemic is one of the deadliest diseases to plague mankind in recent times. Considerable scientific effort from all over the world has been rallied to fight this common foe.
With this free-of-charge TA Call `COVID-19 Therapeutics Pipeline´, INFRAFRONTIER is providing researchers access to test their innovative and novel COVID-19 therapeutics in a standardised infection pipeline that uses preclinical models to study COVID-19 infection.
More details can be found here.
COVID-19 Resources offered by INFRAFRONTIER Partners
The coronavirus (COVID-19) pandemic is not only a serious threat to global public health, it also deeply affects the social and economic life worldwide. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving and distribution of model mammalian genomes, is fully committed to support researchers around the globe to develop a vaccine against SARS-CoV-2 and to find treatments for COVID-19.
Phenomin-ICS, France |
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Phenomin-CIPHE, France |
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Helmholtz Zentrum München, Germany |
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MRC Harwell Institute, United Kingdom |
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Centre National de la Recherche Scientifique (CNRS), France |
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Consiglio Nazionale delle Ricerche (CNR), Italy |
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Czech Centre for Phenogenomics, Institute of Molecular Genetics ASCR, Czech Republic |
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Biomedcode Hellas SA, Greece |
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University of Oulu, Finland |
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BSRC Fleming, Greece |
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Coronaviridae-related EMMA strains
The following EMMA strains are related to SARS-CoV-2 and other Coronaviridae viral infections via their human orthologues. The table below contains EMMA strains that could be used for Coronaviridae infection research.
EM:11531 / HMGU, Susan Marschall: s.marschall@helmholtz-muenchen.de / frozen germplasm EM:05839 / CNR, Marcello Raspa: marcello.raspa@cnr.it / frozen germplasm 'the Spike protein (S) interacts with the GOLGA7-ZDHHC5 acyl-transferase complex, which likely mediates palmitoylation on its cytosolic tail' EMMA Strain Details EM:10456 / ICS, Mohammed Selloum: contact@phenomin.fr / frozen germplasm 'We also identified an interaction of Nsp5 (C145A) with tRNA methyltransferase 1 (TRMT1), which is responsible for synthesis of the dimethylguanosine (m2,2G) base modification on both nuclear and mitochondrial tRNAs40. We predict TRMT1 is also cleaved by Nsp5, removing its zinc finger and nuclear localization signal and likely resulting in an exclusively mitochondrial localization' SARS-CoV-2 invades host cells via a novel route: CD147-spike protein https://www.biorxiv.org/content/10.1101/2020.03.14.988345v1 'Here, we reported a research finding that SARS-CoV-2 invaded host cells via a novel route of CD147-spike protein (SP). SP bound to CD147, a receptor on the host cells, thereby mediating the viral invasion.' EMMA Strain Details EM:06847 / Vetmeduni Vienna, Auke Boersma: emma-vienna@vetmeduni.ac.at / frozen germplasm EM:07748 / Wellcome Trust Sanger Institute, mouseinterest@sanger.ac.uk / frozen germplasm SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells EM:02577 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm EM:09968 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm COVID-19 and diabetes: Can DPP4 inhibition play a role? A mouse model for MERS coronavirus-induced acute respiratory distress syndrome A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV The Proximal Origin of SARS-CoV-2 'the highly variable spike (S) protein of SARS-CoV-2 has a polybasic (furin) cleavage site at the S1 and S2 boundary via the insertion of twelve nucleotides' EM:08708 / ICS, Mohammed Selloum: contact@phenomin.fr; CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm EM:09915 EM:09916 EM:09906 / Vetmeduni Vienna, Auke Boersma: emma-vienna@vetmeduni.ac.at / frozen germplasm EM:06064 and EM:06065 / CNB-CSIC, CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / frozen germplasm SARS-CoV-2 is sensitive to type I interferon pretreatment EM:05332 / CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / Registration of interest is possible. Rederivation and shipments will be processed as soon as the cryopreservation unit at CNB-CSIC becomes operative again after the coronavirus crisis Medical Authorities and Companies launch novel clinical trials of interleukin 6 inhibitors, as the IL-6 pathway could play a role in the overactive inflammatory response observed in lungs of severely and critically ill COVID-19 patients EM:11812 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm EM:08503 EM:08502 / CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / Registration of interest is possible. Rederivation and shipments will be processed as soon as the cryopreservation unit at CNB-CSIC becomes operative again after the coronavirus crisis EM:06164 / HMGU, Susan Marschall: s.marschall@helmholtz-muenchen.de / frozen germplasm EM:05518 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm EM:11987 EM:11988 / MRC Harwell Institute, Martin Fray: m.fray@har.mrc.ac.uk / frozen germplasm EM:09943 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus EMMA Strain Details EM:11132 EM:11144/ Vetmeduni Vienna, Auke Boersma: emma-vienna@vetmeduni.ac.at / frozen germplasm Phenotypes associated with this genotype from MGI: link MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV Phenotypes associated with this genotype from MGI: link Development of a transgenic mouse model susceptible to human coronavirus 229E Phenotypes associated with this genotype from MGI: link IFN-gamma is required for viral clearance from central nervous system oligodendroglia Due to the current coronavirus (COVID-19) situation, there may be a need to urgently archive various valuable mouse models. Please contact us (emma@infrafrontier.eu) for archiving possibilities. In contrast to the standard EMMA archiving service, which includes evaluation by an external scientific committee and is free of charge for depositors, the emergency service may come with service charges. Details will be provided by the EMMA nodes. Here is a list of COVID-19 research resources offered by our European and international partners: Gene
Adam17
EMMA Strain Details EM:04475 / CNB-CSIC, CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / frozen germplasm Reference to Gene and COVID-19 TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Gene
Zdhhc5
EMMA Strain Details Reference to Gene and COVID-19 A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing Gene
Trmt1
Reference to Gene and COVID-19 A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing Gene
Bsg
EMMA Strain Details EM:04318 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm Reference to Gene and COVID-19 Gene
Dhodh
Reference to Gene and COVID-19 Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification Gene
Os9
EMMA Strain Details EM:08172 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm Reference to Gene and COVID-19 Gene
Ptges2
EMMA Strain Details EM:05527 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm Reference to Gene and COVID-19 A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing Gene
Rab5c
EMMA Strain Details EM:07127 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm Reference to Gene and COVID-19 A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing Gene
Tmprss2
EMMA Strain Details EM:09886 / ICS, Mohammed Selloum: contact@phenomin.fr; CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm Reference to Gene and COVID-19 Gene
Retreg3
EMMA Strain Details EM:05438 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm Reference to Gene and COVID-19 Gene
Dpp4
EMMA Strain Details Reference to Gene and COVID-19
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin miceGene
Furin
EMMA Strain Details EM:04412 / CNR, Marcello Raspa: marcello.raspa@cnr.it / frozen germplasm Reference to Gene and COVID-19 Gene
Stat1
EMMA Strain Details Reference to Gene and COVID-19 Gene
Il6
EMMA Strain Details Reference to Gene and COVID-19
http://www.chictr.org.cn/showprojen.aspx?proj=49409
https://www.pmlive.com/pharma_news/sanofi,_regeneron_launch_trials_of_arthritis_drug_kevzara_for_covid-19_1329326Gene
Il10
EMMA Strain Details Reference to Gene and COVID-19 Gene
Myd88
EMMA Strain Details Reference to Gene and COVID-19 MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV Gene
Nrp
EMMA Strain Details Reference to Gene and COVID-19 Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system Gene
Tlr4
EMMA Strain Details EM:00035 / CNRS, Karine Jambou: jambou@cnrs-orleans.fr / frozen germplasm Reference to Gene and COVID-19 Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury Gene
Ifnar1
EMMA Strain Details EM:10181 / University of Oulu, Reetta Hinttala: emma-oulu@oulu.fi / frozen germplasm Reference to Gene and COVID-19 Gene
Ahr
EMMA Strain Details EM:12733 / Czech Centre for Phenogenomics: ccp-tam@img.cas.cz / frozen germplasm Reference to Gene and COVID-19 Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression Gene
Ifih1
EMMA Strain Details EM:11517 / MRC Harwell Institute, Martin Fray: m.fray@har.mrc.ac.uk / frozen germplasm Reference to Gene and COVID-19 Gene
CCr1
Reference to Gene and Coronaviridae infection Gene
Stat1, Tg(ANPEP)270Mmul
EMMA Strain Details EM:06060 EM:06061 / CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / frozen germplasm Reference to Gene and Coronaviridae infection Gene
Ifng
EMMA Strain Details EM:02106 / CNR, Marcello Raspa: marcello.raspa@cnr.it / frozen germplasm Reference to Gene and Coronaviridae infection Gene
Tbk1
EMMA Strain Details EM:07230 / CNB-CSIC, Lluis Montoliu: criocnb@cnb.csic.es / frozen germplasm
EM:12874 / Czech Centre for Phenogenomics: ccp-tam@img.cas.cz / frozen germplasm Reference to Gene and Coronaviridae infection Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Gene
Irf7
EMMA Strain Details EM:06478 / Wellcome Trust Sanger Institute, mouseinterest@sanger.ac.uk / frozen germplasm Reference to Gene and Coronaviridae infection Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Emergency Archiving during COVID-19 crisis
COVID-19 resources from our partners and collaborators