C57BL/10ScCrOrl

Status

Available to order

EMMA IDEM:00035
International strain nameC57BL/10ScCrOrl
Alternative nameC57BL/10ScCR
Strain typeSpontaneous
Allele/Transgene symbolTlr4lps-del,
Gene/Transgene symbolTlr4

Information from provider

ProviderFrancois Huetz
Provider affiliationBat. Metchnikoff, Inst. Pasteur
Phenotypic informationMutant strain carrying an intrinsic Tlr4 deletion (Tlr4: toll-like receptor 4; prev. nomenclature: Lps). No response to Lipopolysaccharide (LPS).
References
  • Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.;Coutinho A, Forni L, Melchers F, Watanabe T, ;1977;European journal of immunology;7;325-8; 326565

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased thermal nociceptive threshold / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal cytokine secretion / MGI
  • abnormal glial cell physiology / MGI
  • decreased response of heart to induced stress / MGI
  • decreased susceptibility to injury / MGI
  • hyporesponsive to tactile stimuli / MGI
  • abnormal retinal rod cell morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal pulmonary alveolar duct morphology / MGI
  • rectal hemorrhage / MGI
  • abnormal retinal layer morphology / MGI
  • enlarged lung / MGI
  • increased spleen weight / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • decreased percent body fat/body weight / MGI
  • increased bone mass / MGI
  • abnormal retinal progenitor cell morphology / MGI
  • abnormal retinal rod bipolar cell morphology / MGI
  • increased bone mineral content / MGI
  • abnormal circulating enzyme level / MGI
  • decreased circulating alanine transaminase level / MGI
  • CNS ischemia / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal tumor necrosis factor level / MGI
  • abnormal neuron differentiation / MGI

Literature references

  • Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.;Coutinho A, Forni L, Melchers F, Watanabe T, ;1977;European journal of immunology;7;325-8; 326565

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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