MGI phenotypes (allele matching)
- reproductive system phenotype / MGI
B6.129S2-Ctsetm1Bchn/H
| Status | Available to order |
| EMMA ID | EM:05211 |
| Citation information | RRID:IMSR_EM:05211 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Ctsetm1Bchn/H |
| Alternative name | CTSEKO_C57Bl |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ctsetm1Bchn |
| Gene/Transgene symbol | Ctse |
Information from provider
| Provider | Benny Chain |
| Provider affiliation | CBU, UCL |
| Genetic information | Cathepsin E deficient mice on a C57BL/6 background (backcrossed for 10 generations). Lacks exons 4 and 5 including active site aspartic acid. |
| Phenotypic information | Mice breed normally. No obvious phenotype has been described as yet but cathepsin E has been implicated in regulation of antigen processing, and other aspects of innate immunity. |
| Breeding history | Generated in 129/Sv and then backcrossed onto C57BL/6 for 10 generations. Now maintained as homozygous colony. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 males |
| Breeding at archiving centre | Males were sperm frozen upon arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
MGI phenotypes (gene matching)
- alopecia / MGI
- reddish skin / MGI
- dermatitis / MGI
- skin lesions / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- mixed cellular infiltration to dermis / MGI
- abnormal immune system physiology / MGI
- abnormal dendritic cell physiology / MGI
- abnormal dendritic cell antigen presentation / MGI
- increased IgE level / MGI
- increased eosinophil cell number / MGI
- increased double-positive T cell number / MGI
- reproductive system phenotype / MGI
- increased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- increased interleukin-4 secretion / MGI
- increased interleukin-5 secretion / MGI
Literature references
- The expression and function of cathepsin E in dendritic cells.;Chain Benjamin M, Free Paul, Medd Patrick, Swetman Claire, Tabor Alethea B, Terrazzini Nadia, ;2005;Journal of immunology (Baltimore, Md. : 1950);174;1791-800; 15699105
- Natural cathepsin E deficiency in the immune system of C57BL/6J mice.;Tulone Calogero, Tsang Jhen, Prokopowicz Zofia, Grosvenor Nicholas, Chain Benny, ;2007;Immunogenetics;59;927-35; 18000662