B6.129S2-Trmt1l^{Gt(W027A02)Wrst}/Ieg

Status	Available to order
EMMA ID	EM:05697
Citation information	RRID:IMSR_EM:05697 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129S2-Trmt1l^{Gt(W027A02)Wrst}/Ieg
Alternative name	Trmt1l (TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae))
Strain type	Gene-trap
Allele/Transgene symbol	Trmt1l^{Gt(W027A02)Wrst}
Gene/Transgene symbol	Trmt1l

Information from provider

Provider	Franz Vauti
Provider affiliation	Cell- & Molecular Biology, Technical University of Braunschweig
Genetic information	Trmt1l PT1betageo gene-trap.
Phenotypic information	Neurobiological phenotype.
Breeding history	Backcrossed to C57BL/6 (N>5).
References	A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583 Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117 The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.;Vauti Franz, Goller Tobias, Beine Rafael, Becker Lore, Klopstock Thomas, Hölter Sabine M, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, de Angelis Martin Hrabé, Arnold Hans-Henning, ;2007;Gene;389;174-85; 17198746
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)

abnormal iron homeostasis / IMPC
thrombocytopenia / IMPC
increased circulating alanine transaminase level / IMPC

Literature references

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.;Wiles M V, Vauti F, Otte J, Füchtbauer E M, Ruiz P, Füchtbauer A, Arnold H H, Lehrach H, Metz T, von Melchner H, Wurst W, ;2000;Nature genetics;24;13-4; 10615117
The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.;Vauti Franz, Goller Tobias, Beine Rafael, Becker Lore, Klopstock Thomas, Hölter Sabine M, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, de Angelis Martin Hrabé, Arnold Hans-Henning, ;2007;Gene;389;174-85; 17198746

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129S2-Trmt1lGt(W027A02)Wrst/Ieg