MGI phenotypes (allele matching)
STOCK Aurkbtm1.1Mama/Cnbc
| Status | Available to order |
| EMMA ID | EM:06109 |
| Citation information | RRID:IMSR_EM:06109 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Aurkbtm1.1Mama/Cnbc |
| Alternative name | Aurkb |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Aurkbtm1.1Mama |
| Gene/Transgene symbol | Aurkb |
Information from provider
| Provider | Marcos Malumbres |
| Provider affiliation | Molecular Oncology, Centro Nacional de Investigaciones Oncologicas (CNIO) |
| Genetic information | A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. |
| Phenotypic information | Before Cre mediated recombination there is no phenotype associated to this allele. |
| Breeding history | Chimeras were crossed with C57BL/6J females for germ line transmission testing. To remove the neoR selection marker Aurkb+/loxfrt mice were crossed with Tg(ACTFLPe)9205Dym mice to remove the frt-flanked neomycin resistance cassette used for homologous recombination selection. Currently maintained by crossing homozygous mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal cell morphology / MGI
- decreased embryo size / MGI
- decreased trophoblast giant cell number / MGI
- edema / MGI
- hemorrhage / MGI
- increased tumor incidence / MGI
- increased skin papilloma incidence / MGI
- premature death / MGI
- abnormal embryonic tissue morphology / MGI
- oligozoospermia / MGI
- abnormal inner cell mass morphology / MGI
- no phenotypic analysis / MGI
- abnormal cell nucleus morphology / MGI
- increased cell nucleus count / MGI
- polyploidy / MGI
- abnormal mitosis / MGI
- abnormal ectoplacental cone morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- embryonic lethality / MGI
- increased adenocarcinoma incidence / MGI
- increased liver adenocarcinoma incidence / MGI
- abnormal mitotic spindle morphology / MGI
- increased fibroblast apoptosis / MGI
- increased embryonic tissue cell apoptosis / MGI
Literature references
- Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.;Fernández-Miranda Gonzalo, Trakala Marianna, Martín Javier, Escobar Beatriz, González Alejandra, Ghyselinck Norbert B, Ortega Sagrario, Cañamero Marta, Pérez de Castro Ignacio, Malumbres Marcos, ;2011;Development (Cambridge, England);138;2661-72; 21613325