B6;129X1-Chmtm1.1Seab/H

Status

Available to order

EMMA IDEM:07826
International strain nameB6;129X1-Chmtm1.1Seab/H
Alternative nameCHM Flox
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolChmtm1.1Seab,
Gene/Transgene symbolChm

Information from provider

ProviderMiguel Seabra
Provider affiliationMolecular Medicine Section, National heart & Lung Institute, Imperial College London
Genetic informationInsertion of two loxP sites flanking exon 4
Phenotypic informationHomozygous:
no phenotype

Heterozygous:
no phenotype
References
  • Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.;Tolmachova Tanya, Anders Ross, Abrink Magnus, Bugeon Laurence, Dallman Margaret J, Futter Clare E, Ramalho José S, Tonagel Felix, Tanimoto Naoyuki, Seeliger Mathias W, Huxley Clare, Seabra Miguel C, ;2006;The Journal of clinical investigation;116;386-94; 16410831
  • Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.;Tolmachova Tanya, Wavre-Shapton Silene T, Barnard Alun R, MacLaren Robert E, Futter Clare E, Seabra Miguel C, ;2010;Investigative ophthalmology & visual science;51;4913-20; 20445111
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Breeding at archiving centreStock was backcrossed to C57BL/6 for four generations, then sib-mated for 20 generations. This stock is homozygous viable.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Literature references

  • Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.;Tolmachova Tanya, Anders Ross, Abrink Magnus, Bugeon Laurence, Dallman Margaret J, Futter Clare E, Ramalho José S, Tonagel Felix, Tanimoto Naoyuki, Seeliger Mathias W, Huxley Clare, Seabra Miguel C, ;2006;The Journal of clinical investigation;116;386-94; 16410831
  • Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.;Tolmachova Tanya, Wavre-Shapton Silene T, Barnard Alun R, MacLaren Robert E, Futter Clare E, Seabra Miguel C, ;2010;Investigative ophthalmology & visual science;51;4913-20; 20445111

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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