B6;129X1-Chmtm1Seab/H
| Status | Available to order |
| EMMA ID | EM:07826 |
| Citation information | RRID:IMSR_EM:07826 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129X1-Chmtm1Seab/H |
| Alternative name | CHM Flox |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Chmtm1Seab |
| Gene/Transgene symbol | Chm |
Information from provider
| Provider | Miguel Seabra |
| Provider affiliation | Molecular Medicine Section, National heart & Lung Institute, Imperial College London |
| Genetic information | Insertion of two loxP sites flanking exon 4 |
| Phenotypic information | Homozygous:no phenotypeHeterozygous:no phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Breeding at archiving centre | Stock was backcrossed to C57BL/6 for four generations, then sib-mated for 20 generations. This stock is homozygous viable. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Choroideremia / Orphanet_180
Literature references
- Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.;Tolmachova Tanya, Anders Ross, Abrink Magnus, Bugeon Laurence, Dallman Margaret J, Futter Clare E, Ramalho José S, Tonagel Felix, Tanimoto Naoyuki, Seeliger Mathias W, Huxley Clare, Seabra Miguel C, ;2006;The Journal of clinical investigation;116;386-94; 16410831
- Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.;Tolmachova Tanya, Wavre-Shapton Silene T, Barnard Alun R, MacLaren Robert E, Futter Clare E, Seabra Miguel C, ;2010;Investigative ophthalmology & visual science;51;4913-20; 20445111