B6;129X1-Chmtm1.1Seab/H
Status | Available to order |
EMMA ID | EM:07826 |
International strain name | B6;129X1-Chmtm1.1Seab/H |
Alternative name | CHM Flox |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Chmtm1.1Seab, |
Gene/Transgene symbol | Chm |
Information from provider
Provider | Miguel Seabra |
Provider affiliation | Molecular Medicine Section, National heart & Lung Institute, Imperial College London |
Genetic information | Insertion of two loxP sites flanking exon 4 |
Phenotypic information | Homozygous:no phenotypeHeterozygous:no phenotype |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Breeding at archiving centre | Stock was backcrossed to C57BL/6 for four generations, then sib-mated for 20 generations. This stock is homozygous viable. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Choroideremia / Orphanet_180
Literature references
- Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.;Tolmachova Tanya, Anders Ross, Abrink Magnus, Bugeon Laurence, Dallman Margaret J, Futter Clare E, Ramalho José S, Tonagel Felix, Tanimoto Naoyuki, Seeliger Mathias W, Huxley Clare, Seabra Miguel C, ;2006;The Journal of clinical investigation;116;386-94; 16410831
- Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.;Tolmachova Tanya, Wavre-Shapton Silene T, Barnard Alun R, MacLaren Robert E, Futter Clare E, Seabra Miguel C, ;2010;Investigative ophthalmology & visual science;51;4913-20; 20445111
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