STOCK MafOfl/H

Status

Available to order

EMMA IDEM:00423
International strain nameSTOCK MafOfl/H
Alternative nameOFL
Strain typeInduced Mutant Strains : Radiation-induced
Allele/Transgene symbolMafOfl,
Gene/Transgene symbolMaf

Information from provider

ProviderMary Lyon
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationMice heterozygous for this mutation have opaque flecks in the lens of their eyes. Mice homozygous for this mutation have very small eyes, and most die at birth through a failure to feed. However, the survivors are small, trembly and develop nephritis.
References
  • A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.;Lyon Mary F, Jamieson Robyn V, Perveen Rahat, Glenister Peter H, Griffiths Robert, Boyd Yvonne, Glimcher Laurie H, Favor Jack, Munier Francis L, Black Graeme C M, ;2003;Human molecular genetics;12;585-94; 12620964

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous 102/H-MafOfl/+, heterozygous (C3H/HeH x 101/H)F1
Stage of embryos8-cell

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • cataract / MGI
  • abnormal pupillary reflex / MGI
  • tremors / MGI
  • decreased body size / MGI
  • abnormal lens induction / MGI
  • microphthalmia / MGI
  • small pupils / MGI
  • increased urine glucose level / MGI
  • abnormal kidney morphology / MGI
  • tubular nephritis / MGI
  • dilated renal tubules / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

Literature references

  • A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.;Lyon Mary F, Jamieson Robyn V, Perveen Rahat, Glenister Peter H, Griffiths Robert, Boyd Yvonne, Glimcher Laurie H, Favor Jack, Munier Francis L, Black Graeme C M, ;2003;Human molecular genetics;12;585-94; 12620964

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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