STOCK Rgs4tm1.1Jbr/Orl

Status

Available to order

EMMA IDEM:01388
International strain nameSTOCK Rgs4tm1.1Jbr/Orl
Alternative nameRgs4lacZ
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolRgs4tm1.1Jbr,
Gene/Transgene symbolRgs4

Information from provider

ProviderJean-François Brunet
Provider affiliationCNRS/ Ecole normale supérieure
Genetic informationProduced by crossing the Rgs4loxFRTlacZ (see EMMA strain EM:01385) strain with a PGK-cre recombinase-expressing mouse strain. Expresses a Rgs4-lacZ fusion from the Rgs4 locus.
Phenotypic informationSubtle coordination deficit. Deficient central integration of pain.
Breeding historyFour backcrosses to C57BL/6.
References
  • Association and linkage analyses of RGS4 polymorphisms in schizophrenia.;Chowdari Kodavali V, Mirnics Karoly, Semwal Prachi, Wood Joel, Lawrence Elizabeth, Bhatia Triptish, Deshpande Smita N, B K Thelma, Ferrell Robert E, Middleton Frank A, Devlin Bernie, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L, ;2002;Human molecular genetics;11;1373-80; 12023979
  • RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.;Rogers J H, Tamirisa P, Kovacs A, Weinheimer C, Courtois M, Blumer K J, Kelly D P, Muslin A J, ;1999;The Journal of clinical investigation;104;567-76; 10487771
  • Generation and characterization of Rgs4 mutant mice.;Grillet Nicolas, Pattyn Alexandre, Contet Candice, Kieffer Brigitte L, Goridis Christo, Brunet Jean-François, ;2005;Molecular and cellular biology;25;4221-8; 15870291

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased body weight / MGI
  • impaired coordination / MGI
  • abnormal touch/ nociception / MGI
  • nervous system phenotype / MGI
  • impaired behavioral response to morphine / MGI
  • decreased behavioral withdrawal response / MGI
  • embryonic lethality between somite formation and embryo turning, incomplete penetrance / MGI

Literature references

  • Association and linkage analyses of RGS4 polymorphisms in schizophrenia.;Chowdari Kodavali V, Mirnics Karoly, Semwal Prachi, Wood Joel, Lawrence Elizabeth, Bhatia Triptish, Deshpande Smita N, B K Thelma, Ferrell Robert E, Middleton Frank A, Devlin Bernie, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L, ;2002;Human molecular genetics;11;1373-80; 12023979
  • RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.;Rogers J H, Tamirisa P, Kovacs A, Weinheimer C, Courtois M, Blumer K J, Kelly D P, Muslin A J, ;1999;The Journal of clinical investigation;104;567-76; 10487771
  • Generation and characterization of Rgs4 mutant mice.;Grillet Nicolas, Pattyn Alexandre, Contet Candice, Kieffer Brigitte L, Goridis Christo, Brunet Jean-François, ;2005;Molecular and cellular biology;25;4221-8; 15870291

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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