STOCK Mut1602/H

Status

Available to order

EMMA IDEM:01951
Citation informationRRID:IMSR_EM:01951 

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International strain nameSTOCK Mut1602/H
Alternative nameMUT/1602
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMut1602
Gene/Transgene symbolMut1602

Information from provider

ProviderBruce Cattanach
Provider affiliationMRC Harwell, Didcot, Oxon, OX11 0RD
Phenotypic informationHeterozygotes are small at birth (over 40% lighter than wild-type sibs) and weaning with white hind feet, short tail and head bobbing. Breeding data suggest that penetrance of the mutation is reduced (circa 65%) and that under 60% survive between birth and weaning. Homozygotes are primarily lost post implantation. There is little or no loss of heterozygotes prior to birth.
Breeding historyOriginal background: (C3H/HeH x 101/H) x PT. Maintained background: C3H/HeH x 101/H. Breeding History: Backcrossed to C3H/HeH x 101/H for several generations.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • embryonic lethality between implantation and placentation, complete penetrance / MGI
  • abnormal foot pad morphology / MGI
  • short tail / MGI
  • decreased body weight / MGI
  • head bobbing / MGI
  • decreased birth weight / MGI
  • postnatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal foot pad morphology / MGI
  • short tail / MGI
  • decreased body weight / MGI
  • head bobbing / MGI
  • decreased birth weight / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality between implantation and placentation, complete penetrance / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
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