B6Brd;B6N-Tyrc-Brd Adam17tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:04475
International strain nameB6Brd;B6N-Tyrc-Brd Adam17tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0051_2_D12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAdam17tm1a(EUCOMM)Wtsi
Gene/Transgene symbolAdam17
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0051_2_D12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal vibrissa morphology / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • hyperplasia / IMPC
  • extramedullary hemopoiesis / IMPC
IMPC phenotypes (gene matching)
  • extramedullary hemopoiesis / IMPC
  • hyperplasia / IMPC
  • abnormal vibrissa morphology / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (allele matching)
  • increased erythrocyte cell number / MGI
  • increased bone mineral content / MGI
  • myeloid hyperplasia / MGI
  • lethality, incomplete penetrance / MGI
  • abnormal vibrissa morphology / MGI
MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • abnormal heart valve morphology / MGI
  • abnormal mitral valve morphology / MGI
  • abnormal coat/ hair morphology / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal hair follicle orientation / MGI
  • distorted hair follicle pattern / MGI
  • waved hair / MGI
  • abnormal small intestine morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • pulmonary hypoplasia / MGI
  • dermatitis / MGI
  • decreased body length / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • curly vibrissae / MGI
  • short vibrissae / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • eyelids open at birth / MGI
  • cataract / MGI
  • abnormal cornea morphology / MGI
  • increased incidence of corneal inflammation / MGI
  • corneal opacity / MGI
  • corneal scarring / MGI
  • abnormal retina morphology / MGI
  • cyanosis / MGI
  • abnormal blood vessel morphology / MGI
  • internal hemorrhage / MGI
  • edema / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • abnormal coat/hair pigmentation / MGI
  • perinatal lethality / MGI
  • premature death / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal eye morphology / MGI
  • abnormal vibrissa morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal tricuspid valve morphology / MGI
  • abnormal atrioventricular valve morphology / MGI
  • abnormal semilunar valve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal pulmonary valve morphology / MGI
  • increased heart weight / MGI
  • thick ventricular wall / MGI
  • aphakia / MGI
  • increased erythrocyte cell number / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • abnormal fetal cardiomyocyte proliferation / MGI
  • abnormal hair follicle development / MGI
  • pathological neovascularization / MGI
  • abnormal lung vasculature morphology / MGI
  • abnormal trabecula carnea morphology / MGI
  • absent Schlemm's canal / MGI
  • absent corneal endothelium / MGI
  • absent Descemet membrane / MGI
  • abnormal respiratory conducting tube morphology / MGI
  • enlarged esophagus / MGI
  • enlarged myocardial fiber / MGI
  • skin inflammation / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal anterior eye segment morphology / MGI
  • abnormal canal of Schlemm morphology / MGI
  • digestive/alimentary phenotype / MGI
  • abnormal platelet physiology / MGI
  • decreased cornea thickness / MGI
  • abnormal corneal epithelium morphology / MGI
  • absent Meibomian glands / MGI
  • abnormal lung epithelium morphology / MGI
  • increased susceptibility to induced colitis / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • abnormal interleukin secretion / MGI
  • increased interleukin-10 secretion / MGI
  • abnormal chemokine level / MGI
  • decreased survivor rate / MGI
  • increased heart ventricle size / MGI
  • decreased transforming growth factor level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • abnormal enterocyte proliferation / MGI
  • failure of eyelid fusion / MGI
  • decreased fetal weight / MGI
  • abnormal mammary gland duct morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • eye opacity / MGI
  • increased bone mineral content / MGI
  • increased susceptibility to weight loss / MGI
  • myeloid hyperplasia / MGI
  • ventricular septal defect / MGI
  • increased heart left ventricle size / MGI
  • enlarged aortic valve / MGI
  • thick aortic valve cusps / MGI
  • thick aortic valve / MGI
  • enlarged pulmonary valve / MGI
  • thick pulmonary valve / MGI
  • thick pulmonary valve cusps / MGI
  • thick tricuspid valve cusps / MGI
  • mortality/aging / MGI
  • abnormal lung saccule morphology / MGI
  • lethality, incomplete penetrance / MGI
  • dilated respiratory conducting tubes / MGI
  • pale lung / MGI
  • abnormal bronchiole epithelium morphology / MGI
  • abnormal branching involved in lung morphogenesis / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • thick lung-associated mesenchyme / MGI
  • anterior iris synechia / MGI
  • vacuolated lens / MGI
  • decreased spongiotrophoblast size / MGI
  • abnormal conjunctival sac morphology / MGI
  • abnormal eyelid margin morphology / MGI
  • enhanced leukocyte tethering or rolling / MGI

Literature references

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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