STOCK Tg(H2Kb-lacZ)1Cba/Orl
| Status | Available to order |
| EMMA ID | EM:05282 |
| International strain name | STOCK Tg(H2Kb-lacZ)1Cba/Orl |
| Alternative name | H-2Z1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(H2Kb-lacZ)1Cba, |
| Gene/Transgene symbol | Tg(H2Kb-lacZ)1Cba |
Information from provider
| Provider | Michel Cohen-Tannoudji |
| Provider affiliation | Departement de Biologie du Développement, Unite de Génétique Fonctionnelle de la Souris, URA 2578 CNRS/Institut Pasteur |
| Genetic information | A 2 kb long H-2Kb 5' regulatory sequence, including the promoter was fused to the E. coli lacZ gene. The construct was then microinjected into (C57BL/6 x SJL/J)F2 fertilized eggs. |
| Phenotypic information | The H-2Z1 transgenic line exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cortex is exactly restricted to the somatosensory area. This marker was used in combination with embryonic cortex transplantation experiments to monitor the establishment of neocortex regionalization. |
| Breeding history | The H-2Z1 line was maintained by successive crosses of H-2Z1 heterozygous males with (C57BL/6 x CBA)F1 females. On other genetic backgrounds, the H-2Z1 expression pattern in the neocortex is expanded. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6 x CBA, wild-type C57BL/6 x CBA |
| Breeding at archiving centre | Transgenic males |
Literature references
- Unexpected position-dependent expression of H-2 and beta 2-microglobulin/lacZ transgenes.;Cohen-Tannoudji M, Morello D, Babinet C, ;1992;Molecular reproduction and development;33;149-59; 1418983
- Early determination of a mouse somatosensory cortex marker.;Cohen-Tannoudji M, Babinet C, Wassef M, ;1994;Nature;368;460-3; 8133892
- Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker.;Gitton Y, Cohen-Tannoudji M, Wassef M, ;1999;Cerebral cortex (New York, N.Y. : 1991);9;611-20; 10498279
- Specification of somatosensory area identity in cortical explants.;Gitton Y, Cohen-Tannoudji M, Wassef M, ;1999;The Journal of neuroscience : the official journal of the Society for Neuroscience;19;4889-98; 10366623