MGI phenotypes (allele matching)
STOCK Aurkbtm1.1Mama/Cnbc
| Status | Available to order |
| EMMA ID | EM:06109 |
| International strain name | STOCK Aurkbtm1.1Mama/Cnbc |
| Alternative name | Aurkb |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Aurkbtm1.1Mama, |
| Gene/Transgene symbol | Aurkb |
Information from provider
| Provider | Marcos Malumbres |
| Provider affiliation | Molecular Oncology, Centro Nacional de Investigaciones Oncologicas (CNIO) |
| Genetic information | A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. |
| Phenotypic information | Before Cre mediated recombination there is no phenotype associated to this allele. |
| Breeding history | Chimeras were crossed with C57BL/6J females for germ line transmission testing. To remove the neoR selection marker Aurkb+/loxfrt mice were crossed with Tg(ACTFLPe)9205Dym mice to remove the frt-flanked neomycin resistance cassette used for homologous recombination selection. Currently maintained by crossing homozygous mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Literature references
- Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.;Fernández-Miranda Gonzalo, Trakala Marianna, Martín Javier, Escobar Beatriz, González Alejandra, Ghyselinck Norbert B, Ortega Sagrario, Cañamero Marta, Pérez de Castro Ignacio, Malumbres Marcos, ;2011;Development (Cambridge, England);138;2661-72; 21613325