MGI phenotypes (allele matching)
B6.129P2-Tbk1tm1Yeh/Cnbc
| Status | Available to order |
| EMMA ID | EM:07230 |
| International strain name | B6.129P2-Tbk1tm1Yeh/Cnbc |
| Alternative name | T2K |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tbk1tm1Yeh, |
| Gene/Transgene symbol | Tbk1 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | Targeting construct deletes exons 1 and 2 of T2K (Tbk1) with neomycin cassette in the opposite direction of transcription. |
| Phenotypic information | The physiological function of T2K (Tbk1) was investigated using T2K-deficient mice. Heterozygotes appear normal, but T2K -/- animals die at approximately E14.5 of massive liver degeneration and apoptosis. Nevertheless, hematopoietic progenitors from T2K-deficient fetal liver support normal lymphocyte development. Furthermore, T2K -/- embryonic fibroblasts and thymocytes do not display increased sensitivity to TNFalpha-induced apoptosis. |
| Breeding history | C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Frontotemporal dementia with motor neuron disease / Orphanet_275872
Literature references
- Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.;Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel W J, Elia A J, Shillinglaw W, Mak T W, Cao Z, Yeh W C, ;2000;The EMBO journal;19;4976-85; 10990461