- abnormal bone structure / IMPC
- increased circulating glucose level / IMPC
- abnormal optic disk morphology / IMPC
- abnormal clavicle morphology / IMPC
- abnormal joint morphology / IMPC
- increased large unstained cell number / IMPC
- increased eosinophil cell number / IMPC
- increased leukocyte cell number / IMPC
STOCK Mapkapk2tm1.2Gkl/Flmg
Status | Available to order |
EMMA ID | EM:08375 |
International strain name | STOCK Mapkapk2tm1.2Gkl/Flmg |
Alternative name | B6-Mapkapk2tm1.2Gkl/Flmg |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Mapkapk2tm1.2Gkl |
Gene/Transgene symbol | Mapkapk2 |
Information from provider
Provider | George Kollias |
Provider affiliation | BSRC Al. Fleming |
Genetic information | Cre-mediated recombination removed the floxed exons 2-5. |
Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- altered response to myocardial infarction / MGI
- impaired macrophage phagocytosis / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal cytokine secretion / MGI
- decreased myocardial infarction size / MGI
- decreased cardiomyocyte apoptosis / MGI
- abnormal macrophage derived foam cell morphology / MGI
- increased spleen germinal center size / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased interleukin-1 beta secretion / MGI
- abnormal cytokine level / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
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