STOCK Mapkapk2tm1.2Gkl/Flmg

Status

Available to order

EMMA IDEM:08375
Citation informationRRID:IMSR_EM:08375 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Mapkapk2tm1.2Gkl/Flmg
Alternative nameB6-Mapkapk2tm1.2Gkl/Flmg
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMapkapk2tm1.2Gkl
Gene/Transgene symbolMapkapk2

Information from provider

ProviderGeorge Kollias
Provider affiliationBSRC Al. Fleming
Genetic informationCre-mediated recombination removed the floxed exons 2-5.
Phenotypic informationHomozygous:
No overt phenotype

Heterozygous:
No overt phenotype
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivinghomozygous C57BL/6J males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • increased circulating glucose level / IMPC
  • abnormal optic disk morphology / IMPC
  • abnormal clavicle morphology / IMPC
  • abnormal joint morphology / IMPC
  • increased large unstained cell number / IMPC
  • increased eosinophil cell number / IMPC
  • increased leukocyte cell number / IMPC
MGI phenotypes (gene matching)
  • altered response to myocardial infarction / MGI
  • impaired macrophage phagocytosis / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal cytokine secretion / MGI
  • decreased myocardial infarction size / MGI
  • decreased cardiomyocyte apoptosis / MGI
  • abnormal macrophage derived foam cell morphology / MGI
  • increased spleen germinal center size / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-1 beta secretion / MGI
  • abnormal cytokine level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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