STOCK Men1tm1.2Zqw/Flmg
| Status | Available to order |
| EMMA ID | EM:09502 |
| International strain name | STOCK Men1tm1.2Zqw/Flmg |
| Alternative name | Men1floxed/floxed |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Men1tm1.2Zqw, |
| Gene/Transgene symbol | Men1 |
Information from provider
| Provider | Philippe Bertolino |
| Provider affiliation | Cancer Research Center of Lyon |
| Genetic information | Mice carrying the homozygous floxed Men1 allele. |
| Phenotypic information | Homozygous:No phenotype has been observed.Heterozygous:No phenotype has been observed. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous mixed 129, C57BL/6, wild-type C57BL/6J |
| Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pituitary gigantism / Orphanet_99725
- Familial isolated hyperparathyroidism / Orphanet_99879
- Multiple endocrine neoplasia type 1 / Orphanet_652
Literature references
- Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.;Bertolino Philippe, Radovanovic Ivan, Casse Huguette, Aguzzi Adriano, Wang Zhao-Qi, Zhang Chang-Xian, ;2003;Mechanisms of development;120;549-60; 12782272
- Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice.;Bertolino Philippe, Tong Wei-Min, Herrera Pedro Luis, Casse Huguette, Zhang Chang Xian, Wang Zhao-Qi, ;2003;Cancer research;63;4836-41; 12941803