IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
STOCK Ralatm1.2Cjm/H
| Status | Available to order |
| EMMA ID | EM:10002 |
| Citation information | RRID:IMSR_EM:10002 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Ralatm1.2Cjm/H |
| Alternative name | RalA |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ralatm1.2Cjm |
| Gene/Transgene symbol | Rala |
Information from provider
| Provider | Afshan McCarthy |
| Provider affiliation | Cancer Biology, Institute of Cancer Research |
| Genetic information | Conditionally targeted allele of RalA. |
| Phenotypic information | Homozygous:Floxed homozygotes are healthy, fertile and have a normal life span.Heterozygous:Floxed heterozygotes are healthy, fertile and have a normal life span. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6J males |
| Breeding at archiving centre | No additional breeding was done at the repository |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal inner ear morphology / MGI
- abnormal ureter morphology / MGI
- abnormal forebrain morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal hindbrain morphology / MGI
- exencephaly / MGI
- small superior cervical ganglion / MGI
- abnormal lens morphology / MGI
- intraventricular hemorrhage / MGI
- abnormal brain morphology / MGI
- abnormal eye muscle morphology / MGI
- abnormal Mullerian duct morphology / MGI
- abnormal Wolffian duct morphology / MGI
- retroesophageal right subclavian artery / MGI
- abnormal optic stalk morphology / MGI
- fusion of vertebral arches / MGI
- coloboma / MGI
- abnormal humerus morphology / MGI
- cellular phenotype / MGI
- spinal hemorrhage / MGI
- abnormal cystic duct morphology / MGI
- abnormal spinal cord central canal morphology / MGI
- muscular ventricular septal defect / MGI
- preweaning lethality, complete penetrance / MGI
- enlarged brain ventricles / MGI
- abnormal vertebral artery morphology / MGI
- absent segment of posterior cerebral artery / MGI
- abnormal ductus venosus morphology / MGI
- abnormal ductus venosus valve morphology / MGI
- multiple persisting craniopharyngeal ducts / MGI
- reduced sympathetic cervical ganglion size / MGI
- blood in lymph vessels / MGI
- abnormal vitelline vein topology / MGI
- anastomosis between internal carotid artery and basilar artery / MGI
- abnormal vertebral artery topology / MGI
- embryo cyst / MGI
- hemangioma / MGI
- retrolental blood / MGI
Literature references
- Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.;Peschard Pascal, McCarthy Afshan, Leblanc-Dominguez Valérie, Yeo Maggie, Guichard Sabrina, Stamp Gordon, Marshall Christopher J, ;2012;Current biology : CB;22;2063-8; 23063435