- decreased circulating LDL cholesterol level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- decreased neutrophil cell number / IMPC
- decreased monocyte cell number / IMPC
- tremors / IMPC
- increased circulating phosphate level / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- decreased eosinophil cell number / IMPC
- increased B cell number / IMPC
- decreased T cell number / IMPC
- increased circulating sodium level / IMPC
- decreased NK T cell number / IMPC
- decreased NK cell number / IMPC
- decreased CD4-positive, alpha beta T cell number / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased total body fat amount / IMPC
- decreased grip strength / IMPC
- increased bone mineral content / IMPC
- decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
- decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased alpha-beta T cell number / IMPC
- decreased Ly6C high monocyte number / IMPC
- decreased Ly6C low monocyte number / IMPC
C57BL/6N-Atm1Brd Dlg4tm1e(EUCOMM)Wtsi/WtsiCnrm
Status | Available to order |
EMMA ID | EM:10013 |
International strain name | C57BL/6N-Atm1Brd Dlg4tm1e(EUCOMM)Wtsi/WtsiCnrm |
Alternative name | EPD0677_5_B02 |
Strain type | Targeted Mutant Strains : Targeted Non-conditional |
Allele/Transgene symbol | Dlg4tm1e(EUCOMM)Wtsi |
Gene/Transgene symbol | Dlg4 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0677_5_B02. For further details on the construction of this clone see the page at the IMPC portal. The targeted allele has lost the 3' loxP site. These mutations cannot be converted into conditional alleles. Click here for more information on EUCOMM final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (allele matching)
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