C57BL/6-Tg(KRT14-TCL1A)1Rso/Cnrm
| Status | Available to order |
| EMMA ID | EM:10036 |
| International strain name | C57BL/6-Tg(KRT14-TCL1A)1Rso/Cnrm |
| Alternative name | K14–hTCL1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-TCL1A)1Rso, |
| Gene/Transgene symbol | Tg(KRT14-TCL1A)1Rso |
Information from provider
| Provider | Giandomenico Russo |
| Provider affiliation | Oncologia Molecolare, IDI-IRCCS |
| Genetic information | Human TCL1A oncogene is overexpressed under the promoter of cytokeratin 14, which is mainly expressed in the basal keratinocytes of skin, in the hair follicle and epithelial cells. |
| Phenotypic information | Homozygous:Restoration of TCL1 expression in the skin and hair follicle of Tcl1 null mice is able to rescue the stem cells compartment and the alopecia and ulcers phenotypes. No tumor development was detected.Heterozygous:same as homozygous |
| Breeding history | The F1 animals were intercrossed for at least 20 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression.;Ragone G, Bresin A, Piermarini F, Lazzeri C, Picchio M C, Remotti D, Kang S-M, Cooper M D, Croce C M, Narducci M G, Russo G, ;2009;Oncogene;28;1329-38; 19169282