C57BL/6N-Atm1Brd Bmp10tm3a(EUCOMM)Hmgu/Ics

Status

Available to order

EMMA IDEM:10046
Citation informationRRID:IMSR_EM:10046 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Bmp10tm3a(EUCOMM)Hmgu/Ics
Alternative nameHEPD0651_3_D08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolBmp10tm3a(EUCOMM)Hmgu
Gene/Transgene symbolBmp10
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0651_3_D08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous males, wild-type C57BL/6NTac females
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased exploration in new environment / IMPC
  • improved glucose tolerance / IMPC
  • decreased circulating creatinine level / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • abnormal heart morphology / MGI
  • abnormal heart development / MGI
  • enlarged heart / MGI
  • abnormal heart shape / MGI
  • ventricular hypoplasia / MGI
  • thin ventricular wall / MGI
  • double outlet right ventricle / MGI
  • enlarged pericardium / MGI
  • trabecula carnea hypoplasia / MGI
  • absent atrioventricular cushions / MGI
  • decreased embryo size / MGI
  • absent vitelline blood vessels / MGI
  • embryonic growth arrest / MGI
  • pericardial edema / MGI
  • thymus hypoplasia / MGI
  • hemorrhage / MGI
  • no abnormal phenotype detected / MGI
  • hydrops fetalis / MGI
  • heart hypoplasia / MGI
  • curly tail / MGI
  • dilated dorsal aorta / MGI
  • abnormal vitelline vascular remodeling / MGI
  • abnormal cardinal vein morphology / MGI
  • decreased heart rate / MGI
  • embryo phenotype / MGI
  • cardiovascular system phenotype / MGI
  • arteriovenous malformation / MGI
  • polycystic kidney / MGI
  • petechiae / MGI
  • ventricular septal defect / MGI
  • subarterial ventricular septal defect / MGI
  • pulmonary artery hypoplasia / MGI
  • absent conotruncal ridges / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased fetal cardiomyocyte proliferation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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