IMPC phenotypes (gene matching)
C57BL/6N-Ppargtm1c(KOMP)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:10145 |
| Citation information | RRID:IMSR_EM:10145 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Ppargtm1c(KOMP)Wtsi/H |
| Alternative name | EPD0395_2_A02 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Ppargtm1c(KOMP)Wtsi |
| Gene/Transgene symbol | Pparg |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from KOMP ES clone EPD0395_2_A02, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Berardinelli-Seip congenital lipodystrophy / Orphanet_528
- PPARG-related familial partial lipodystrophy / Orphanet_79083
MGI phenotypes (gene matching)
- abnormal adipose tissue distribution / MGI
- abnormal bone marrow development / MGI
- abnormal triglyceride level / MGI
- hypertension / MGI
- abnormal heart development / MGI
- abnormal myocardial fiber morphology / MGI
- thin ventricular wall / MGI
- enlarged liver / MGI
- abnormal hepatocyte morphology / MGI
- decreased body weight / MGI
- hyperactivity / MGI
- hyperlipidemia / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- abnormal circulating alanine transaminase level / MGI
- extended life span / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- placental labyrinth hypoplasia / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- decreased brown adipose tissue amount / MGI
- decreased white adipose tissue amount / MGI
- abnormal humoral immune response / MGI
- reduced fertility / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- prenatal lethality / MGI
- premature death / MGI
- abnormal lipid homeostasis / MGI
- no abnormal phenotype detected / MGI
- abnormal myocardial trabeculae morphology / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal bone marrow morphology / MGI
- abnormal B cell physiology / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- hepatic steatosis / MGI
- decreased circulating triglyceride level / MGI
- thin myocardium / MGI
- decreased circulating free fatty acid level / MGI
- decreased circulating insulin level / MGI
- abnormal retinal vasculature morphology / MGI
- increased systemic arterial blood pressure / MGI
- decreased systemic arterial blood pressure / MGI
- increased insulin sensitivity / MGI
- abnormal white adipose tissue morphology / MGI
- abnormal brown adipose tissue morphology / MGI
- increased liver weight / MGI
- no phenotypic analysis / MGI
- increased susceptibility to induced arthritis / MGI
- abnormal bone structure / MGI
- embryonic growth retardation / MGI
- increased incidence of tumors by chemical induction / MGI
- abnormal chorionic plate morphology / MGI
- increased adiponectin level / MGI
- decreased adiponectin level / MGI
- increased osteoblast cell number / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal trophoblast giant cell morphology / MGI
- abnormal cell differentiation / MGI
- increased B cell proliferation / MGI
- abnormal response to injury / MGI
- increased circulating cholesterol level / MGI
- decreased circulating cholesterol level / MGI
- abnormal pancreatic islet morphology / MGI
- improved glucose tolerance / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- abnormal gonadal fat pad morphology / MGI
- abnormal inguinal fat pad morphology / MGI
- increased circulating aspartate transaminase level / MGI
- liver/biliary system phenotype / MGI
- adipose tissue phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- pancreatic islet hyperplasia / MGI
- increased body temperature / MGI
- decreased body temperature / MGI
- increased circulating glucose level / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- increased circulating leptin level / MGI
- abnormal white adipose tissue physiology / MGI
- decreased body mass index / MGI
- increased fat cell size / MGI
- abnormal epididymal fat pad morphology / MGI
- abnormal bone ossification / MGI
- abnormal osteoblast differentiation / MGI
- leukostasis / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-2 secretion / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- absent subcutaneous adipose tissue / MGI
- decreased subcutaneous adipose tissue amount / MGI
- decreased total fat pad weight / MGI
- pancreas hyperplasia / MGI
- abnormal fat cell morphology / MGI
- abnormal brown fat cell morphology / MGI
- abnormal white fat cell morphology / MGI
- increased brown fat cell size / MGI
- decreased brown fat cell lipid droplet size / MGI
- decreased white fat cell number / MGI
- abnormal white fat cell size / MGI
- decreased white fat cell size / MGI
- decreased brown fat lipid droplet number / MGI
- abnormal endocrine pancreas morphology / MGI
- decreased gonadal fat pad weight / MGI
- decreased inguinal fat pad weight / MGI
- increased interscapular fat pad weight / MGI
- decreased retroperitoneal fat pad weight / MGI
- increased liver triglyceride level / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased total body fat amount / MGI
- thin ventricle myocardium compact layer / MGI
- thin interventricular septum / MGI
- increased trabecular bone mass / MGI
- abnormal circadian temperature homeostasis / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- lipodystrophy / MGI
- decreased food intake / MGI
- increased fluid intake / MGI
- abnormal placenta hemotrichorial membrane morphology / MGI
- decreased white adipose tissue mass / MGI
- decreased brown adipose tissue mass / MGI
- increased adipocyte glucose uptake / MGI
- decreased muscle cell glucose uptake / MGI