MGI phenotypes (allele matching)
B6.129S4-Rasgrf1tm2Pds/Cnrm
| Status | Available to order |
| EMMA ID | EM:10177 |
| International strain name | B6.129S4-Rasgrf1tm2Pds/Cnrm |
| Alternative name | Rasgrf1tm2Pds |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Rasgrf1tm2Pds, |
| Gene/Transgene symbol | Rasgrf1 |
Information from provider
| Provider | Riccardo Brambilla |
| Provider affiliation | School of Biosciences, Cardiff University |
| Genetic information | Ras-GRF1 mutant mouse. |
| Phenotypic information | Homozygous:None, the mutation is only evident in one allele.Heterozygous:Imprinted methylation of the paternal Rasgrf1 allele is removed, allowing biallelic expression. In addition, this mutant shows overexpression of the Ras-GRF1 protein and alterations both in memory consolidation and behavioural responses to drugs of abuse. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker.;Yoon Bongjune, Herman Herry, Hu Benjamin, Park Yoon Jung, Lindroth Anders, Bell Adam, West Adam G, Chang Yanjie, Stablewski Aimee, Piel Jessica C, Loukinov Dmitri I, Lobanenkov Victor V, Soloway Paul D, ;2005;Molecular and cellular biology;25;11184-90; 16314537
- Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.;Fasano Stefania, D'Antoni Angela, Orban Paul C, Valjent Emmanuel, Putignano Elena, Vara Hugo, Pizzorusso Tommaso, Giustetto Maurizio, Yoon Bongjune, Soloway Paul, Maldonado Rafael, Caboche Jocelyne, Brambilla Riccardo, ;2009;Biological psychiatry;66;758-68; 19446794