C57BL/6N-Atm1Brd Ehmt1tm1a(EUCOMM)Hmgu/WtsiCnrm

Status

Available to order

EMMA IDEM:10184
Citation informationRRID:IMSR_EM:10184 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Ehmt1tm1a(EUCOMM)Hmgu/WtsiCnrm
Alternative nameHEPD0734_3_F01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolEhmt1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolEhmt1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0734_3_F01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • increased thigmotaxis / IMPC
  • increased circulating LDL cholesterol level / IMPC
  • decreased locomotor activity / IMPC
  • increased grip strength / IMPC
  • decreased exploration in new environment / IMPC
  • decreased circulating creatinine level / IMPC
  • decreased blood urea nitrogen level / IMPC
  • abnormal behavior / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased mean platelet volume / IMPC
  • increased neutrophil cell number / IMPC
  • corneal opacity / IMPC
  • increased anxiety-related response / IMPC
  • increased lean body mass / IMPC
MGI phenotypes (gene matching)
  • abnormal nasal bone morphology / MGI
  • malocclusion / MGI
  • open neural tube / MGI
  • abnormal social investigation / MGI
  • increased anxiety-related response / MGI
  • decreased anxiety-related response / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal suckling behavior / MGI
  • abnormal object recognition memory / MGI
  • increased startle reflex / MGI
  • incomplete somite formation / MGI
  • postnatal growth retardation / MGI
  • impaired synaptic plasticity / MGI
  • abnormal associative learning / MGI
  • abnormal sensory capabilities/reflexes/nociception / MGI
  • no abnormal phenotype detected / MGI
  • abnormal social/conspecific interaction / MGI
  • decreased vertical activity / MGI
  • enhanced paired-pulse facilitation / MGI
  • delayed intramembranous bone ossification / MGI
  • abnormal response to novel object / MGI
  • abnormal metopic suture morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • abnormal dendrite morphology / MGI
  • decreased survivor rate / MGI
  • decreased embryo weight / MGI
  • decreased fetal weight / MGI
  • impaired contextual conditioning behavior / MGI
  • impaired cued conditioning behavior / MGI
  • absent gastric milk in neonates / MGI
  • decreased birth body size / MGI
  • abnormal dendritic spine morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • prenatal growth retardation / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal epigenetic regulation of gene expression / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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