STOCK Lipatm1a(EUCOMM)Hmgu/Biat

Status

Available to order

EMMA IDEM:10357
Citation informationRRID:IMSR_EM:10357 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Lipatm1a(EUCOMM)Hmgu/Biat
Alternative nameStock Lipa/Biat
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLipatm1a(EUCOMM)Hmgu
Gene/Transgene symbolLipa

Information from provider

ProviderDagmar Kratky
Provider affiliationInstitute of Molecular Biology and Biochemistry Center for Molecular Medicine, Medical University of Graz
Genetic informationMouse line originates from EUCOMM clone HEPD0960_2_H11 injected into BALB/c blastocysts
Phenotypic informationHomozygous:
unknown

Heterozygous:
unknown
References
  • Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.;Leopold Christina, Duta-Mare Madalina, Sachdev Vinay, Goeritzer Madeleine, Maresch Lisa Katharina, Kolb Dagmar, Reicher Helga, Wagner Bettina, Stojakovic Tatjana, Ruelicke Thomas, Haemmerle Guenter, Hoefler Gerald, Sattler Wolfgang, Kratky Dagmar, ;2019;Biochimica et biophysica acta. Molecular and cell biology of lipids;1864;500-511; 30639734
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivingheterozygous C57BL/6N males
Breeding at archiving centreINFRAFRONTIER-I3 WP8 line produced by ES cell injection at Vetmed.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • abnormal intestine morphology / MGI
  • abnormal small intestine morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal liver morphology / MGI
  • enlarged liver / MGI
  • abnormal hepatocyte morphology / MGI
  • abnormal adrenal gland morphology / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • abnormal choroid plexus morphology / MGI
  • abnormal lung morphology / MGI
  • decreased body weight / MGI
  • abnormal lipid level / MGI
  • increased circulating free fatty acid level / MGI
  • decreased brown adipose tissue amount / MGI
  • decreased white adipose tissue amount / MGI
  • lung inflammation / MGI
  • emphysema / MGI
  • increased circulating insulin level / MGI
  • premature death / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal type II pneumocyte morphology / MGI
  • chronic inflammation / MGI
  • hepatic steatosis / MGI
  • abnormal brown adipose tissue morphology / MGI
  • increased liver weight / MGI
  • abnormal duodenum morphology / MGI
  • abnormal jejunum morphology / MGI
  • increased spleen weight / MGI
  • pale kidney / MGI
  • insulin resistance / MGI
  • abnormal inguinal fat pad morphology / MGI
  • abnormal retroperitoneal fat pad morphology / MGI
  • increased Clara cell number / MGI
  • abnormal interscapular fat pad morphology / MGI
  • abnormal small intestinal villus morphology / MGI
  • abnormal Kupffer cell morphology / MGI
  • abnormal alveolar macrophage morphology / MGI
  • enlarged mesenteric lymph nodes / MGI
  • absent subcutaneous adipose tissue / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal liver sinusoid morphology / MGI
  • increased brown fat cell lipid droplet size / MGI
  • abnormal white fat cell size / MGI
  • decreased epididymal fat pad weight / MGI
  • increased liver triglyceride level / MGI
  • increased liver cholesterol level / MGI
  • increased type II pneumocyte number / MGI
  • increased food intake / MGI

Literature references

  • Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.;Leopold Christina, Duta-Mare Madalina, Sachdev Vinay, Goeritzer Madeleine, Maresch Lisa Katharina, Kolb Dagmar, Reicher Helga, Wagner Bettina, Stojakovic Tatjana, Ruelicke Thomas, Haemmerle Guenter, Hoefler Gerald, Sattler Wolfgang, Kratky Dagmar, ;2019;Biochimica et biophysica acta. Molecular and cell biology of lipids;1864;500-511; 30639734

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Availabilities

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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