IMPC phenotypes (gene matching)
B6.Cg-Rock1tm1.1Skmp/SkmpH
| Status | Available to order |
| EMMA ID | EM:10372 |
| Citation information | RRID:IMSR_EM:10372 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Rock1tm1.1Skmp/SkmpH |
| Alternative name | Rock1 (C57Bl6J) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rock1tm1.1Skmp |
| Gene/Transgene symbol | Rock1 |
Information from provider
| Provider | Afshan McCarthy |
| Provider affiliation | Cancer Biology, Institute of Cancer Research |
| Genetic information | Conditionally targeted allele of Rock1. |
| Phenotypic information | Homozygous:Floxed homozygous mice are viable and have a normal lifespan.Heterozygous:Floxed heterozygous mice are viable and have a normal lifespan. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6J males |
| Breeding at archiving centre | No additional breeding was done at the repository |
Disease and phenotype information
Literature references
- Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.;Kümper Sandra, Mardakheh Faraz K, McCarthy Afshan, Yeo Maggie, Stamp Gordon W, Paul Angela, Worboys Jonathan, Sadok Amine, Jørgensen Claus, Guichard Sabrina, Marshall Christopher J, ;2016;eLife;5;e12994; 26765561