- abnormal dorsal root ganglion morphology / MGI
- abnormal mechanical nociception / MGI
- allodynia / MGI
- abnormal axon extension / MGI
- decreased thermal nociceptive threshold / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal neurite morphology / MGI
- decreased survivor rate / MGI
- prenatal lethality, incomplete penetrance / MGI
- impaired central nervous system regeneration / MGI
STOCK Aviltm1(HBEGF)Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:10409 |
| Citation information | RRID:IMSR_EM:10409 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Aviltm1(HBEGF)Phep/Cnrm |
| Alternative name | Avil-iDTR |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Aviltm1(HBEGF)Phep |
| Gene/Transgene symbol | Avil |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | Adriano Buzzati-Traverso Campus, EMBL Monterotondo |
| Genetic information | A cre recombinase-inducible iDTR (primate diphtheria toxin receptor, now heparin-binding EGF-like growth factor or HBEGF) cassette has been inserted into the advillin locus replacing exon 2 and 66 bp upstream thereof, creating a permanent null modification. |
| Phenotypic information | When crossed with an appropriate cre recombinase-expressing line allows diphtheria toxin-mediated ablation of sensory neurons. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.;Stantcheva Kalina K, Iovino Loredana, Dhandapani Rahul, Martinez Concepcion, Castaldi Laura, Nocchi Linda, Perlas Emerald, Portulano Carla, Pesaresi Martina, Shirlekar Kalyanee S, de Castro Reis Fernanda, Paparountas Triantafillos, Bilbao Daniel, Heppenstall Paul A, ;2016;EMBO reports;17;585-600; 26929027
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