C57BL/6N-Ccnd2tm1a(KOMP)Mbp/H

Status

Available to order

EMMA IDEM:10566
Citation informationRRID:IMSR_EM:10566 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Ccnd2tm1a(KOMP)Mbp/H
Alternative nameDEPD00008_1_A01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCcnd2tm1a(KOMP)Mbp
Gene/Transgene symbolCcnd2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone DEPD00008_1_A01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac males
Breeding at archiving centreThe mutation was generated on a coisogenic C57BL/6NTac background

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome / Orphanet_83473
IMPC phenotypes (gene matching)
  • abnormal cranium morphology / IMPC
  • increased lean body mass / IMPC
  • increased grip strength / IMPC
  • hyperactivity / IMPC
  • trunk curl / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • small testis / IMPC
  • increased circulating phosphate level / IMPC
  • increased circulating glucose level / IMPC
  • increased circulating iron level / IMPC
  • impaired glucose tolerance / IMPC
  • decreased total body fat amount / IMPC
  • increased bone mineral content / IMPC
  • abnormal spine curvature / IMPC
  • increased mean corpuscular volume / IMPC
  • increased fasting circulating glucose level / IMPC

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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